Listar por autor "fb585e21-8eed-4d0f-bd0b-f1689525d0d7"
Mostrando ítems 1-18 de 18
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A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep
Molina Hernández, Verónica; Ruiz-Campillo, María Teresa; Martínez-Moreno, Francisco Javier; Buffoni Perazzo, Leandro; Martínez-Moreno, Álvaro; Zafra Leva, Rafael; Escamilla, Alejandro; Pérez Caballero, Raúl; Pérez Arévalo, José (MDPI, 2021)Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the ... -
A pathological and immunohistochemical study of intestinal bowel desease in dogs
Raduan Jaber, J.; Farray, David; Pérez, José; Zucca, D.; Castro, P.; Zafra Leva, Rafael; Rodríguez, F. (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016)This study describes the histopathological and immunohistochemical characteristics of 41 dogs with clinical signs of inflammatory bowel disease (IBD) -
Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep
Escamilla, Alejandro; Pérez Caballero, Raúl; Zafra Leva, Rafael; Bautista, M.J.; Pacheco, I.L.; Ruiz, M.Teresa; Martínez Cruz, Setefilla; Martínez-Moreno, Álvaro; Molina Hernández, Verónica; Pérez, José (Elsevier, 2017)Several immunomodulatory properties have been described in Fasciola hepatica infections. Apoptosis has been shown to be an effective mechanism to avoid the immune response in helminth infections. The aim of the present ... -
Caracterización de macrófagos peritoneales de ovejas en fases tempranas de infección experimental con fasciola hepática
Zafra Leva, Rafael; Pacheco, I.L.; Escamilla, Alejandro; Caballero, R.; Buffoni Perazzo, Leandro; Molina Hernández, Verónica; Martínez-Moreno, Álvaro; Pérez, José; Ruiz-Campillo, María Teresa (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016) -
Distribución de linfocitos FOXP3 reguladores en hígado y nódulos linfáticos de ovejas y cabras infectadas con fasciola hepática
Escamilla, Alejandro; Zafra Leva, Rafael; Bautista Pérez, María José; Pacheco, I.L.; Ruiz-Campillo, María Teresa; Martínez-Moreno, Álvaro; Molina Hernández, Verónica; Pérez, José (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016) -
Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica
Escamilla, Alejandro; Zafra Leva, Rafael; Pérez, José; McNeilly, T.N.; Pacheco, I.L.; Buffoni Perazzo, Leandro; Martínez-Moreno, Francisco Javier; Molina Hernández, Verónica; Martínez-Moreno, Álvaro (Elsevier, 2016)Foxp3 regulatory T cells (Tregs) are now considered to play a key role in modulation of immune responses during parasitic helminth infections. Immunomodulation is a key factor in Fasciola hepatica infection; however, the ... -
Estudio histopatológico e inmunohistoquímico del hígado y ganglios linfáticos hepáticos en cabras inmunizadas frente a "Fasciola hepatica"
Zafra Leva, Rafael (Universidad de Córdoba, Servicio de Publicaciones, 2007-12-14)El objetivo del presente estudio ha sido evaluar la eficacia protectora, así como las lesiones y respuestas inmune local y sistémica inducidas por los antígenos Glutatión-S-Transferasa (GST) de F.hepatica y un péptido ... -
Expresión génica de IL4 e INFΓ en hígado y nódulo linfático hepático en ovejas vacunadas con CL1 infectadas con Fasciola hepática
Pacheco, I.L.; Abril, Nieves; Morales-Prieto, N.; Bautista Pérez, María José; Ruiz, M.Teresa; Zafra Leva, Rafael; Escamilla, Alejandro; Martínez-Moreno, Álvaro; Pérez, José (2017-11-30) -
Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep
Escamilla, Alejandro; Bautista, M.J.; Zafra Leva, Rafael; Pacheco, I.L.; Ruiz, M.Teresa; Martínez Cruz, Setefilla; Méndez, A.; Martínez-Moreno, Álvaro; Molina Hernández, Verónica; Pérez, José (Elsevier, 2016)The aim of the present work was to evaluate the number of apoptotic eosinophils in the livers of sheep experimentally infected with Fasciola hepatica during the migratory and biliary stages of infection. Four groups (n = ... -
Fasciola hepatica primoinfections and reinfections in sheep drive distinct Th1/Th2/Treg immune responses in liver and hepatic lymph node at early and late stages
Ruiz-Campillo, María Teresa; Barrero‑Torres, Diana María; Abril, Nieves; Pérez, José; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Molina-Hernández, Verónica (Springer, 2023)The expression of proinflammatory (IL-1β, IFN-γ, TNF-α) and regulatory (IL-10, TGF-β, IL-4) cytokines, as well as the transcription factor FoxP3, was quantified in the liver and hepatic lymph node (HLN) of sheep primoinfected ... -
Hepatopancreatic ganglioneuroma in a young dog: a case report
Zafra Leva, Rafael; Bautista Pérez, María José; Pérez, José; Ginel Pérez, Pedro J.; Lucena Solís, Rosario (Czech Academy of Agricultural Sciences., 2011)The clinical, pathological and immunohistochemical features of a hepatobiliary and pancreatic ganglioneuroma in a seven-month-old dog are described. The dog presented progressive weight loss, anorexia and abdominal pain. ... -
Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica
Pacheco, I.L.; Abril, Nieves; Zafra Leva, Rafael; Morales-Prieto, N.; Molina Hernández, Verónica; Ruiz, M.T.; Pérez Caballero, Raúl; Martínez-Moreno, Álvaro; Pérez, José (Nature.com, 2019)The aim of this study was to validate reference genes for gene normalisation using qRT-PCR in hepatic lymph nodes (HLN) and livers from sheep infected with Fasciola hepatica during early and late stages of infection. To ... -
Immunohistochemical study of nonspecific reactive hepatitis in dogs
Velázquez-Wallraf, A.; Pérez, José; Carrascosa, C.; Zafra Leva, Rafael; Raduan Jaber, J. (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016) -
Megaesófago de origen inmunomediado en perro
Zafra Leva, Rafael; Pacheco, I.L.; Escamilla, Alejandro; López-Rasero, J.; Mozos Mora, Elena; Bautista Pérez, María José; Méndez-Sánchez, Aniceto; Pérez, José; Ruiz-Campillo, María Teresa (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016) -
Revealing the Prevalence of Toxoplasma in Sierra Morena’s Wild Boar: An ELISA-Based Study Using Meat Juice
Castillo-Castillo, José María; Rufino-Moya, Pablo José; Martínez Moreno, Álvaro; Salvador Castaño, Ángela; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael (MDPI, 2024)This research work focused on the prevalence of Toxoplasma gondii in wild boar from the Sierra Morena region. We conducted an ELISA analysis using meat juice samples. A total of 892 samples from six hunting seasons (2013–2019) ... -
The Sigma Class Glutathione Transferase from the Liver Fluke Fasciola hepatica
LaCourse, E. James; Perally, Samirah; Morphew, Russell M.; Moxon, Joseph V.; Prescott, Mark; Dowling, David J.; O'Neill, Sandra M.; Kipar, Anja; Hetzel, Udo; Hoey, Elizabeth; Brophy, Peter M.; Pérez, José; Zafra Leva, Rafael; Buffoni Perazzo, Leandro (Public Library Of Science (PLOS), 2012)Background: Liver fluke infection of livestock causes economic losses of over US$ 3 billion worldwide per annum. The disease is increasing in livestock worldwide and is a re-emerging human disease. There are currently no ... -
Uterine and ovarian remnants in an incorrectly spayed bitch: a case report
Pérez-Marín, C.C.; Molina, L.; Vizuete Calero, Guillermo; Sánchez, J.M.; Zafra Leva, Rafael; Bautista Pérez, María José (Czech Academy of Agricultural Sciences, 2014)A spayed Samoyed bitch, 12 years old, was presented to the Veterinary Clinical Hospital of the University of Cordoba (Spain) with abundant vulvar sanguineous discharge over the previous three days. The clinical examination ... -
Vaccines against helminth parasites of livestock of economic and/or public health significance (PARAVAC)
Zafra Leva, Rafael; Pérez, José; Escamilla, Alejandro; Buffoni Perazzo, Leandro; Pérez Caballero, Raúl; Redacción TR-UCO (Oficina de Transferencia de Resultados de la Investigación, 2013)El proyecto PARAVAC está financiado por el VII Programa Marco con una aportación de la Comisión Europea de unos 9 millones de euros. El principal objetivo de este proyecto es el desarrollo y comercialización de vacunas ...