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dc.contributor.authorRangel Zúñiga, Oriol Alberto
dc.contributor.authorCamargo García, A.
dc.contributor.authorMarín, Carmen
dc.contributor.authorPeña Orihuela, Judhit
dc.contributor.authorPérez-Martínez, Pablo
dc.contributor.authorDelgado-Lista, Javier
dc.contributor.authorGonzález Guardia, Lorena
dc.contributor.authorYubero-Serrano, Elena M.
dc.contributor.authorTinahones, Francisco J.
dc.contributor.authorMalagón, María M.
dc.contributor.authorPérez-Jiménez, Francisco
dc.contributor.authorRoche, Helen M.
dc.contributor.authorLópez-Miranda, José
dc.date.accessioned2017-12-07T10:32:37Z
dc.date.available2017-12-07T10:32:37Z
dc.date.issued2015
dc.identifier.citationBMC Genomics 16:509 (2015)es_ES
dc.identifier.urihttp://hdl.handle.net/10396/15665
dc.description.abstractBackground: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including dietary habits. We aimed to identify the target proteins modulated by the long-term consumption of four diets differing in the quality and quantity of lipids in the whole proteome of peripheral blood mononuclear cells (PBMC). Results: A randomized, controlled trial conducted within the LIPGENE study assigned 24 MetS patients for 12 weeks each to 1 of 4 diets: a) high-saturated fatty acid (HSFA), b) high-monounsaturated fatty acid (HMUFA), c) low-fat, high-complex carbohydrate diets supplemented with placebo (LFHCC) and d) low-fat, high-complex carbohydrate diets supplemented with long chain (LC) n-3 polyunsaturated fatty acids (PUFA) (LFHCC n-3). We analyzed the changes induced in the proteome of both nuclear and cytoplasmic fractions of PBMC using 2-D proteomic analysis. Sixty-seven proteins were differentially expressed after the long-term consumption of the four diets. The HSFA diet induced the expression of proteins responding to oxidative stress, degradation of ubiquitinated proteins and DNA repair. However, HMUFA, LFHCC and LFHCC n-3 diets down-regulated pro-inflammatory and oxidative stress-related proteins and DNA repairing proteins. Conclusion: The long-term consumption of HSFA, compared to HMUFA, LFHCC and LFHCC n-3, seems to increase the cardiovascular disease (CVD) risk factors associated with metabolic syndrome, such as inflammation and oxidative stress, and seem lead to DNA damage as a consequence of high oxidative stress.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/es/es_ES
dc.subjectMetabolic syndromees_ES
dc.subjectProteomicses_ES
dc.subjectInflammationes_ES
dc.subjectOxidative stresses_ES
dc.subjectDNA damagees_ES
dc.titleProteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipidses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1186/s12864-015-1725-8es_ES
dc.relation.projectIDUnión Europea. 505944 (LIPGENE)es_ES
dc.relation.projectIDGobierno de España. AGL2004-07907es_ES
dc.relation.projectIDGobierno de España. AGL2006-01979es_ES
dc.relation.projectIDGobierno de España. AGL2009-12270es_ES
dc.relation.projectIDInstituto de Salud Carlos III. CB06/03/0047 (CIBEROBN)es_ES
dc.relation.projectIDJunta de Andalucía. P06-CTS-01425es_ES
dc.relation.projectIDJunta de Andalucía. CTS-03039es_ES
dc.relation.projectIDJunta de Andalucía. 06/128es_ES
dc.relation.projectIDJunta de Andalucía. 07/43es_ES
dc.relation.projectIDJunta de Andalucía. PI-0193es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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