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Mostrando ítems 54-73 de 86

    • Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease 

      Muñoz-Castañeda, Juan R.; Rodelo Haad, Cristian Roberto; Pendón-Ruiz de Mier, María V.; Martín-Malo, Alejandro; Santamaría, Rafael; Rodríguez, Mariano (MDPI, 2020)
      Fibroblast Growth Factor 23 (FGF23) and Klotho play an essential role in the regulation of mineral metabolism, and both are altered as a consequence of renal failure. FGF23 increases to augment phosphaturia, which prevents ...

    • Long-term effect of a dietary intervention with two-healthy dietary approaches on food intake and nutrient density in coronary patients: results from the CORDIOPREV trial 

      Cano‑Ibáñez, Naomi; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Yubero-Serrano, Elena M.; Pérez‑Corral, Isabel; Arenas de Larriva, Antonio P.; García-Ríos, Antonio; Pérez-Martínez, Pablo; Delgado-Lista, Javier; López-Miranda, José (Springer, 2022)
      Background: Cardiovascular disease (CVD) is the leading cause of disease burden in the world by non-communicable diseases. Nutritional interventions promoting high-quality dietary patterns with low caloric intake value and ...

    • Lumbalgia y ejercicio físico 

      Pérez-Guisado, Joaquín (Comunidad Virtual Ciencias del Deporte y Universidad Autónoma de Madrid, 2006)
      La lumbalgia es un problema que se caracteriza por su alta prevalencia en la población, de hecho hasta el 80% de la población lo padece al menos una vez en la vida En cerca del 90% de los casos no se encuentra ningún tipo ...

    • Magnesium Inhibits Wnt/β-Catenin Activity and Reverses the Osteogenic Transformation of Vascular Smooth Muscle Cells 

      Montes de Oca, Addy; Guerrero Pavón, Fátima; Martínez-Moreno, Julio M.; Madueño, Juan A.; Herencia, Carmen; Peralta, Alan; Almadén Peña, Yolanda; López, Ignacio; Aguilera Tejero, Escolástico; Gundlach, Kristina; Büchel, Janine; Peter, Mirjam E.; Passlick-Deetjen, Jutta; Rodríguez Portillo, Mariano; Muñoz-Castañeda, Juan R. (Public Library of Science, 2014)
      Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly increased magnesium levels and aimed at determining: a) whether ...

    • Magnesium Replacement to Protect Cardiovascular and Kidney Damage? Lack of Prospective Clinical Trials 

      Muñoz-Castañeda, Juan R.; Pendón-Ruiz de Mier, María V.; Rodríguez, Mariano; Rodríguez-Ortiz, Maria E. (MDPI, 2018)
      Patients with advanced chronic kidney disease exhibit an increase in cardiovascular mortality. Recent works have shown that low levels of magnesium are associated with increased cardiovascular and all-cause mortality in ...

    • Measuring Spinal Mobility Using an Inertial Measurement Unit System: A Validation Study in Axial Spondyloarthritis 

      Aranda-Valera, I. Concepción; Cuesta-Vargas, Antonio; Garrido Castro, Juan Luis; Gardiner, Philip V.; López Medina, Eloísa Clementina; Machado, Pedro M.; Condell, Joan; Connolly, James; Williams, Jonathan M.; Muñoz-Esquivel, Karla; O’Dwyer, Tom; Castro Villegas, María del Carmen; González-Navas, Cristina; Collantes Estévez, Eduardo; iMaxSpA Study Group (MDPI, 2020)
      Portable inertial measurement units (IMUs) are beginning to be used in human motion analysis. These devices can be useful for the evaluation of spinal mobility in individuals with axial spondyloarthritis (axSpA). The ...

    • Mechanical Properties of Lumbar and Cervical Paravertebral Muscles in Patients with Axial Spondyloarthritis: A Case-Control Study 

      Garrido Castro, Juan Luis; Aranda-Valera, I. Concepción; Peña Amaro, J.; Martínez Galisteo, A.; González-Navas, Cristina; Rodrigues-de-Souza, Daiana Priscila; Alcaraz-Clariana, Sandra; García-Luque, Lourdes; Martínez Sánchez, Iago R.; López Medina, Eloísa Clementina; Collantes Estévez, Eduardo; Alburquerque Sendín, Francisco (MDPI, 2021)
      Background: Axial spondyloarthritis (axSpA) affects spinal muscles, due to inflammation and structural damage. The mechanical properties of the muscles, such as tone or stiffness, could be altered in axSpA. The aim of this ...

    • Medication Non-Adherence in Rheumatology, Oncology and Cardiology: A Review of the Literature of Risk Factors and Potential Interventions 

      Gil-Guillen, Vicente F.; Balsa, Alejandro; Bernárdez, Beatriz; Valdés y Llorca, Carmen; Márquez-Contreras, Emilio; Haba-Rodríguez, Juan R. de la; Castellano, J.M.; Gómez-Martínez, Jesús (MDPI, 2022)
      Medication adherence is directly associated with health outcomes. Adherence has been reviewed extensively; however, most studies provide a narrow scope of the problem, covering a specific disease or treatment. This project’s ...

    • Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer 

      Mena-Osuna, Rafael; Mantrana, Ana; Guil-Luna, Silvia; Sánchez, María-Teresa; Navarrete, Carmen; Morales-Ruiz, T.; Rivas-Crespo, Aurora; Toledano-Fonseca, Marta; García-Ortíz, María Victoria; García Jurado, Gema; Gómez-España, M. Auxiliadora; González Fernández, Rafael A.; Villar, Carlos; Medina Fernández, Francisco Javier; Villalba, José Manuel; Aranda Aguilar, Enrique; Rodríguez-Ariza, Antonio (Wiley, 2023)
      S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible are still largely unclear. In this study, we show that GSNOR ...

    • Método de obtención de datos útiles para predecir la respuesta al tratamiento de la Hepatitis C 

      Peña Martínez, José; Torre-Cisneros, Julián de la; Rivero Román, Antonio; González Fernández, Rafael A.; Manzanares Martín, Bárbara; Rivero Juárez, Antonio; Camacho Espejo, Ángela (Oficina de Transferencia de Resultados de la Investigación, 2013)
      La presente invención proporciona un método de obtención de datos útiles para predecir cual será la respuesta de un paciente al tratamiento de la hepatitis C, específicamente al tratamiento con interferón pegilado y ...

    • mTOR Expression in Liver Transplant Candidates with Hepatocellular Carcinoma: Impact on Histological Features and Tumour Recurrence 

      Guerrero, Marta; Ferrín, Gustavo; Rodríguez-Perálvarez, Manuel; González Rubio, Sandra; Sánchez-Frías, Marina; Amado-Torres, Víctor; Pozo, Juan C.; Poyato, Antonio; Ciria, Rubén; Ayllón Terán, M. Dolores; Barrera, Pilar; Montero, José L.; Mata, Manuel de la (MDPI, 2019)
      (1) Background: The mammalian target of rapamycin (mTOR) pathway activation is critical for hepatocellular carcinoma (HCC) progression. We aimed to evaluate the mTOR tissue expresión in liver transplant (LT) patients and ...

    • Nuclear Translocation of b-Catenin during Mesenchymal Stem Cells Differentiation into Hepatocytes Is Associated with a Tumoral Phenotype 

      Herencia, Carmen; Martínez-Moreno, Julio M.; Herrera, Concepción; Corrales, Fernando J.; Santiago-Mora, Raquel; Espejo, Isabel; Barcos, Montserrat; Almadén Peña, Yolanda; Mata, Manuel de la; Rodríguez-Ariza, Antonio; Muñoz-Castañeda, Juan R. (Public Libray of Science (PLOS), 2012)
      Wnt/b-catenin pathway controls biochemical processes related to cell differentiation. In committed cells the alteration of this pathway has been associated with tumors as hepatocellular carcinoma or hepatoblastoma. The ...

    • NUTRITECH 

      López-Miranda, José (Oficina de Transferencia de Resultados de la Investigación, 2013)
      NutriTech is a European Commission funded FP7 research project (2012-2015) The goal of NutriTech is to quantify the effect of diet on “phenotypic flexibility”. Phenotypic flexibility extends on metabolic flexibility (the ...

    • Owning a Pet Is Associated with Changes in the Composition of Gut Microbiota and Could Influence the Risk of Metabolic Disorders in Humans 

      Arenas-Montes, Javier; Pérez-Martínez, Pablo; Vals-Delgado, Cristina; Romero-Cabrera, Juan Luis; Cardelo, Magdalena P.; León Acuña, Ana; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; López-Miranda, José; Camargo García, A.; Pérez-Jiménez, Francisco (MDPI, 2021)
      Pet ownership positively influences clinical outcomes in cardiovascular prevention. Additionally, cardiovascular disease (CVD) has been previously linked to microbiota dysbiosis. We evaluated the influence of owning a pet ...

    • Paravertebral Muscle Mechanical Properties in Patients with Axial Spondyloarthritis or Low Back Pain: A Case-Control Study 

      Alcaraz-Clariana, Sandra; García-Luque, Lourdes; Garrido Castro, Juan Luis; Aranda-Valera, I. Concepción; Ladehesa-Pineda, Lourdes; Puche-Larrubia, María Ángeles; Carmona-Pérez, Cristina; Rodrigues-de-Souza, Daiana Priscila; Alburquerque Sendín, Francisco (MDPI, 2021)
      Different musculoskeletal disorders are a source of pain in the spinal region; most of them can be divided into mechanical, such as low back pain (LBP), or inflammatory origins, as is the case of axial spondyloarthritis ...

    • Patients with Axial Spondyloarthritis Show an Altered Flexion/Relaxation Phenomenon 

      Aranda-Valera, I. Concepción; Garrido Castro, Juan Luis; Martínez Galisteo, A.; Peña Amaro, J.; González-Navas, Cristina; Cuesta-Vargas, Antonio; Jiménez Reina, L.; Collantes Estévez, Eduardo; López Medina, Eloísa Clementina (MDPI, 2021)
      Axial spondyloarthritis (axSpA) is a chronic rheumatic disease characterized by the presence of inflammatory back pain. In patients with chronic low back pain, the lumbar flexion relaxation phenomenon measured by surface ...

    • Perspectivas y oportunidades de colaboración entre el IMIBIC y el ceiA3 

      Pérez-Jiménez, Francisco (Campus de Excelencia Internacional Agroalimentaria, 2010)

    • Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance 

      Boughanem, Hatim; Yubero-Serrano, Elena M.; López-Miranda, José; Tinahones, Francisco J.; Macías-González, Manuel (MDPI, 2021)
      Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic ...

    • Prevalence and Associated Factors of Low Bone Mineral Density in the Femoral Neck and Total Hip in Axial Spondyloarthritis: Data from the CASTRO Cohort 

      Bautista-Aguilar, Laura; López Medina, Eloísa Clementina; Ladehesa-Pineda, Lourdes; Ábalos-Aguilera, María del Carmen; Ruiz-Vilchez, Desirée; Garrido Castro, Juan Luis; Gómez-García, Ignacio; Puche-Larrubia, María Ángeles; Salmoral-Chamizo, Asunción; Collantes Estévez, Eduardo; Escudero Contreras, Alejandro; Font-Ugalde, Pilar (MDPI, 2021)
      Studies on osteoporosis in axial spondyloarthritis (axSpA) have focused on the lumbar segment, and few studies have assessed bone mineral density (BMD) in the hip and femoral neck in these patients. The aim of this study ...

    • Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids 

      Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Marín, Carmen; Peña Orihuela, Judhit; Pérez-Martínez, Pablo; Delgado-Lista, Javier; González Guardia, Lorena; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Malagón, María M.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José (BioMed Central, 2015)
      Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including ...