Listar Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología por autor "fb585e21-8eed-4d0f-bd0b-f1689525d0d7"
Mostrando ítems 1-20 de 24
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A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep
Molina Hernández, Verónica; Ruiz-Campillo, María Teresa; Martínez-Moreno, Francisco Javier; Buffoni Perazzo, Leandro; Martínez-Moreno, Álvaro; Zafra Leva, Rafael; Escamilla, Alejandro; Pérez Caballero, Raúl; Pérez Arévalo, José (MDPI, 2021)Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the ... -
A pathological and immunohistochemical study of intestinal bowel desease in dogs
Raduan Jaber, J.; Farray, David; Pérez, José; Zucca, D.; Castro, P.; Zafra Leva, Rafael; Rodríguez, F. (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016)This study describes the histopathological and immunohistochemical characteristics of 41 dogs with clinical signs of inflammatory bowel disease (IBD) -
Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep
Escamilla, Alejandro; Pérez Caballero, Raúl; Zafra Leva, Rafael; Bautista, M.J.; Pacheco, I.L.; Ruiz, M.Teresa; Martínez Cruz, Setefilla; Martínez-Moreno, Álvaro; Molina Hernández, Verónica; Pérez, José (Elsevier, 2017)Several immunomodulatory properties have been described in Fasciola hepatica infections. Apoptosis has been shown to be an effective mechanism to avoid the immune response in helminth infections. The aim of the present ... -
Caracterización de macrófagos peritoneales de ovejas en fases tempranas de infección experimental con fasciola hepática
Zafra Leva, Rafael; Pacheco, I.L.; Escamilla, Alejandro; Caballero, R.; Buffoni Perazzo, Leandro; Molina Hernández, Verónica; Martínez-Moreno, Álvaro; Pérez, José; Ruiz-Campillo, María Teresa (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016) -
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
Ruiz-Campillo, María Teresa; Molina-Hernández, Verónica; Bautista, María José; Pacheco, I.L.; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Martínez-Moreno, Francisco Javier; Martínez Moreno, Álvaro; Pérez, José (Springer, 2020)Fasciola hepatica has been shown to have a high capacity for immunomodulation of the host response, making the development of protective vaccines extremely difficult. One of these immunomodulation mechanisms is the impairment ... -
Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis
Pérez Caballero, Raúl; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Molina-Hernández, Verónica; Pacheco, I.L.; Ruiz-Campillo, María Teresa; Escamilla, Alejandro; Pérez, José; Martínez Moreno, Álvaro; Buffoni Perazzo, Leandro (Springer, 2018)Background: The peritoneal cell populations (PCP) are thought to play a crucial role during the early immune response in Fasciola hepatica infection while newly excysted juveniles (NEJ) are migrating in the peritoneal ... -
Distribución de linfocitos FOXP3 reguladores en hígado y nódulos linfáticos de ovejas y cabras infectadas con fasciola hepática
Escamilla, Alejandro; Zafra Leva, Rafael; Bautista Pérez, María José; Pacheco, I.L.; Ruiz-Campillo, María Teresa; Martínez-Moreno, Álvaro; Molina Hernández, Verónica; Pérez, José (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016) -
Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica
Escamilla, Alejandro; Zafra Leva, Rafael; Pérez, José; McNeilly, T.N.; Pacheco, I.L.; Buffoni Perazzo, Leandro; Martínez-Moreno, Francisco Javier; Molina Hernández, Verónica; Martínez-Moreno, Álvaro (Elsevier, 2016)Foxp3 regulatory T cells (Tregs) are now considered to play a key role in modulation of immune responses during parasitic helminth infections. Immunomodulation is a key factor in Fasciola hepatica infection; however, the ... -
Estudio histopatológico e inmunohistoquímico del hígado y ganglios linfáticos hepáticos en cabras inmunizadas frente a "Fasciola hepatica"
Zafra Leva, Rafael (Universidad de Córdoba, Servicio de Publicaciones, 2007-12-14)El objetivo del presente estudio ha sido evaluar la eficacia protectora, así como las lesiones y respuestas inmune local y sistémica inducidas por los antígenos Glutatión-S-Transferasa (GST) de F.hepatica y un péptido ... -
Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica
Ruiz-Campillo, María Teresa; Pacheco, I.L.; Abril, Nieves; Bautista, M.J.; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Buffoni Perazzo, Leandro; Pérez, J.; Molina-Hernández, Verónica; Zafra Leva, Rafael (BMC (Springer), 2024)Gene expression for Th1/Th2 cytokines (IL-4 and IFN-ɣ), regulatory cytokines (TGF-β and IL-10) and the transcriptional factor FoxP3 was analyzed in the liver and hepatic lymph nodes (HLN) from sheep immunized with partially ... -
Expresión génica de IL4 e INFΓ en hígado y nódulo linfático hepático en ovejas vacunadas con CL1 infectadas con Fasciola hepática
Pacheco, I.L.; Abril, Nieves; Morales-Prieto, N.; Bautista Pérez, María José; Ruiz, M.Teresa; Zafra Leva, Rafael; Escamilla, Alejandro; Martínez-Moreno, Álvaro; Pérez, José (2017-11-30) -
Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection
Pérez Caballero, Raúl; Buffoni Perazzo, Leandro; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Molina-Hernández, Verónica; Pérez, José; Martínez Moreno, Álvaro (Springer, 2018)Background: The majority of vaccination studies against infection with F. hepatica in a natural host have been conducted at the late stage of the infection when the host's immune response is already immunomodulated by the ... -
Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep
Escamilla, Alejandro; Bautista, M.J.; Zafra Leva, Rafael; Pacheco, I.L.; Ruiz, M.Teresa; Martínez Cruz, Setefilla; Méndez, A.; Martínez-Moreno, Álvaro; Molina Hernández, Verónica; Pérez, José (Elsevier, 2016)The aim of the present work was to evaluate the number of apoptotic eosinophils in the livers of sheep experimentally infected with Fasciola hepatica during the migratory and biliary stages of infection. Four groups (n = ... -
Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection
Pacheco, Isabel; Abril, Nieves; Zafra Leva, Rafael; Molina-Hernández, Verónica; Morales‑Prieto2, Noelia; Bautista, M.J.; Ruiz-Campillo, María Teresa; Pérez Caballero, Raúl; Martínez Moreno, Álvaro; Pérez, José (Springer, 2018)The expression of T regulatory cells (Foxp3), regulatory (interleukin [IL]-10 and transforming growth factor beta [TGF-β]) and proinflammatory (tumor necrosis factor alpha [TNF-α] and interleukin [IL]-1β) cytokines was ... -
Fasciola hepatica primoinfections and reinfections in sheep drive distinct Th1/Th2/Treg immune responses in liver and hepatic lymph node at early and late stages
Ruiz-Campillo, María Teresa; Barrero‑Torres, Diana María; Abril, Nieves; Pérez, José; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Molina-Hernández, Verónica (Springer, 2023)The expression of proinflammatory (IL-1β, IFN-γ, TNF-α) and regulatory (IL-10, TGF-β, IL-4) cytokines, as well as the transcription factor FoxP3, was quantified in the liver and hepatic lymph node (HLN) of sheep primoinfected ... -
Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
Flores Velazquez, Luis Miguel; Ruiz-Campillo, María Teresa; Herrera-Torres, Guillem; Martínez Moreno, Álvaro; Martínez-Moreno, Francisco Javier; Zafra Leva, Rafael; Buffoni Perazzo, Leandro; Rufino-Moya, Pablo José; Molina-Hernández, Verónica; Pérez, José (Frontiers, 2023)Fasciola hepatica has a worldwide distribution causing important economic losses in animal production industry. Human fasciolosis is considered an emerging zoonosis in areas of Andean America, Asia, and Africa. The control ... -
Hepatopancreatic ganglioneuroma in a young dog: a case report
Zafra Leva, Rafael; Bautista Pérez, María José; Pérez, José; Ginel Pérez, Pedro J.; Lucena Solís, Rosario (Czech Academy of Agricultural Sciences., 2011)The clinical, pathological and immunohistochemical features of a hepatobiliary and pancreatic ganglioneuroma in a seven-month-old dog are described. The dog presented progressive weight loss, anorexia and abdominal pain. ... -
Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach
Buffoni Perazzo, Leandro; Garza-Cuartero, Laura; Pérez Caballero, Raúl; Zafra Leva, Rafael; Martínez-Moreno, Francisco Javier; Molina-Hernández, Verónica; Pérez, José; Martínez Moreno, Álvaro; Mulcahy, Grace (Springer, 2020)Background: Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies gave rise to the identification of various vaccine candidates. The recombinant form of a member ... -
Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica
Pacheco, I.L.; Abril, Nieves; Zafra Leva, Rafael; Morales-Prieto, N.; Molina Hernández, Verónica; Ruiz, M.T.; Pérez Caballero, Raúl; Martínez-Moreno, Álvaro; Pérez, José (Nature.com, 2019)The aim of this study was to validate reference genes for gene normalisation using qRT-PCR in hepatic lymph nodes (HLN) and livers from sheep infected with Fasciola hepatica during early and late stages of infection. To ... -
Immunohistochemical study of nonspecific reactive hepatitis in dogs
Velázquez-Wallraf, A.; Pérez, José; Carrascosa, C.; Zafra Leva, Rafael; Raduan Jaber, J. (Universidad de Córdoba. Departamento de Anatomía y Anatomía Patológica Comparadas, 2016)