Nitrogen Oxyanion-dependent Dissociation of a Two-component Complex That Regulates Bacterial Nitrate Assimilation
Autor
Luque-Almagro, Víctor Manuel
Lyall, Verity J.
Ferguson, Stuart J.
Richardson, David J.
Gates, Andrew J.
Roldán, María Dolores
Editor
American Society for Biochemistry and Molecular BiologyFecha
2013Materia
NitrogenNitrate assimilation
NasS gene
NasT gene
Biochemistry
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Background: Nitrogen oxyanion-responsive two-component regulators that control assimilatory nitrate metabolism in
heterotrophic bacteria are poorly characterized.
Results: The nasT and nasS genes encode a regulatory complex that dissociates upon sensing nitrate/nitrite, releasing the
RNA-binding protein NasT.
Conclusion: NasS-NasT is a two-component regulator for nitrate/nitrite perception.
Significance: A nitrate/nitrite-sensitive interaction between NasS and NasT has been demonstrated for the first time.