Surveillance of Drug-Resistant Tuberculosis in Spain (2001–2015)
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Autor
Gutiérrez-Aroca, Juan-Bautista
Ruiz, Pilar
Vaquero Abellán, Manuel
Causse, Manuel
Casal Román, Manuel
Editor
Mary Ann Liebert, Inc.Fecha
2018Materia
TuberculosisResistance
Mycobacterium
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Multidrug-resistant (MDR) tuberculosis (TB) is a cause of increasing concern. This study investigated first-line
anti-TB drug resistance in Mycobacterium tuberculosis strains submitted to the Tuberculosis Reference Center in
Co´rdoba (Spain) between 2001 and 2015. A total of 1,207 cultures were tested against first-line drugs using the
BACTEC MGIT 960 system. Resistance to first-line drugs was detected in 207 strains (17.2%), the greatest
resistance being found in INH (5.3%) followed by streptomycin (3%), pyrazinamide (2.2%), rifampicin (1%), and
ethambutol (0.2%). A total of 1.9% of strains were MDR. Six strains displayed resistance to four drugs, and three
strains to five drugs. In view of resistance observed, careful surveillance of drug resistance is recommended