DBCFI-Artículos, capítulos...
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Puede ver todos los artículos producidos en la Universidad de Córdoba en la colección Artículos, capítulos… UCO.
Los contenidos se encuentran sujetos bajo una Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing
(Springer Nature, 2023)Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the ... -
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing
(Wiley, 2022)Introduction: Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellularmachinery controlling this process (spliceosome components and splicing factors) in ... -
Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study
(Elsevier, 2018)Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ... -
Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma
(Elsevier, 2020)Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1 (SF3B1) is a crucial splicing factor that can be targeted pharmacologically (e.g. pladienolide-B). Here, we show that SF3B1 is ... -
Peptides derived from the extracellular domain of the somatostatin receptor splicing variant 1 SST5TMD4 increase malignancy in multiple cancer cell types
(Elsevier, 2019)Extracellular fragments derived from plasma membrane receptors can play relevant roles in the development/progression of tumor pathologies, thereby offering novel diagnostic or therapeutic opportunities. The truncated ...