Listar OpenAIRE (Open Access Infrastructure for Research in Europe) por autor "8e2a8d47-4e90-4421-9dc6-2476d8235b24"

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    • Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition 

      Tapia-González, S.; García-Segura, L.M.; Tena-Sempere, Manuel; Frago, L.M.; Castellano, J.M.; Fuente-Martín, E.; García-Cáceres, C.; Argente, J.; Chowen, J.A. (Blackwell Publishing, 2011)
      Much attention has been drawn to the possible involvement of hypothalamic inflammation in the pathogenesis of metabolic disorders, especially in response to a high-fat diet. Microglia, the macrophages of the central nervous ...

    • Comparative insights of the kisspeptin/kisspeptin receptor system: lessons from non-mammalian vertebrates 

      Tena-Sempere, Manuel; Felip, Alicia; Gómez, Ana; Zanuy, Silvia; Carrillo, Manuel (Elsevier, 2012)
      Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as ligands of the G protein‐coupled receptor 54 (GPR54; also termed Kiss1R) with ability to suppress tumor metastasis. In late 2003, ...

    • Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin 

      Martins, Luis; Fernández-Mayo, Diana; Novelle, Marta G.; Vázquez, María J.; Nogeiras, Rubén; López, Miguel; Diéguez, Carlos; Tena-Sempere, Manuel (Public Library Of Science (PLOS), 2012)
      Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase ...

    • Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue 

      Novelle, Marta G.; Vázquez, María J.; Peinado, Juan R.; Martinello, Kátia D.; López, Miguel; Luckman, Simon M.; Tena-Sempere, Manuel; Malagón, María M.; Nogueiras, Rubén; Diéguez, Carlos (Nature Research, 2017)
      During their lifetime, females are subjected to different nutritional and hormonal factors that could increase the risk of obesity and associated comorbidities. From early postnatal periods until the postmenopausal phase, ...

    • The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy 

      Lozoya, Teresa; Domínguez, Francisco; Romero-Ruiz, Antonio; Steffani, Liliana; Martínez, Sebastián; Monterde, Mercedes; Ferri, Blanca; Núñez, María José; Romero- Espino, Ainoha; Zamora, Omar; Gurrea, Marta; Sangiao-Alvarellos, Susana; Vega, Olivia; Simón, Carlos; Pellicer, Antonio; Tena-Sempere, Manuel (PLOS, 2014)
      Our objective was to determine the expression of the elements of the Lin28/Let-7 system, and related microRNAs (miRNAs), in early stages of human placentation and ectopic pregnancy, as a means to assess the potential role ...