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Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis
(Springer, 2018)
Background: The peritoneal cell populations (PCP) are thought to play a crucial role during the early immune response in Fasciola hepatica infection while newly excysted juveniles (NEJ) are migrating in the peritoneal ...
Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection
(Springer, 2018)
The expression of T regulatory cells (Foxp3), regulatory (interleukin [IL]-10 and transforming growth factor beta [TGF-β]) and proinflammatory (tumor necrosis factor alpha [TNF-α] and interleukin [IL]-1β) cytokines was ...
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
(Springer, 2020)
Fasciola hepatica has been shown to have a high capacity for immunomodulation of the host response, making the development of protective vaccines extremely difficult. One of these immunomodulation mechanisms is the impairment ...
Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach
(Springer, 2020)
Background: Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies
gave rise to the identification of various vaccine candidates. The recombinant form of a member ...
Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
(Frontiers, 2023)
Fasciola hepatica has a worldwide distribution causing important economic losses in animal production industry. Human fasciolosis is considered an emerging zoonosis in areas of Andean America, Asia, and Africa. The control ...
Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection
(Springer, 2018)
Background: The majority of vaccination studies against infection with F. hepatica in a natural host have been conducted at the late stage of the infection when the host's immune response is already immunomodulated by the ...