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Proto-oncogene HER-2 in normal, dysplastic and tumorous feline mammary glands: an immunohistochemical and chromogenic in situ hybridization study
dc.contributor.author | Ordás, Javier | |
dc.contributor.author | Millán Ruiz, Yolanda | |
dc.contributor.author | Reymundo, Carlos | |
dc.contributor.author | Martín de las Mulas González-Albo, Juana | |
dc.contributor.author | Dios Palomares, Rafaela | |
dc.date.accessioned | 2013-06-27T08:48:42Z | |
dc.date.available | 2013-06-27T08:48:42Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | http://hdl.handle.net/10396/10584 | |
dc.description.abstract | Background: Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. Methods: Formalin-fixed, paraffin-embedded tissue samples from 30 invasive carcinomas, 7 benign lesions and two normal mammary glands were analyzed. Tumour features with prognostic value were recorded. The expression of protein HER-2 was analyzed by immunohistochemistry and the number of gene copies by means of DNA chromogenic in situ hybridization. Results: Immunohistochemical HER-2 protein overexpression was found in 40% of feline mammary carcinomas, a percentage higher to that observed in human breast carcinoma. As in women, feline tumours with HER-2 protein overexpression had pathological features of high malignancy. However, amplification of HER-2 was detected in 16% of carcinomas with protein overexpression, a percentage much lower than that observed in their human counterpart. Conclusion: Feline mammary carcinoma would be a suitable natural model of that subset of human breast carcinomas with HER-2 protein overexpression without gene amplification. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BioMed Central | es_ES |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.source | BMC Cancer 7 (2007) | es_ES |
dc.subject | Feline mammary carcinoma | es_ES |
dc.subject | Immunohistochemistry | es_ES |
dc.subject | Cancer | es_ES |
dc.title | Proto-oncogene HER-2 in normal, dysplastic and tumorous feline mammary glands: an immunohistochemical and chromogenic in situ hybridization study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |