Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study)
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Author
Talavera-García, Eva
Delgado-Lista, Javier
García-Ríos, Antonio
Delgado-Casado, Nieves
Gómez-Luna, Purificación
Gómez-Garduño, Ángela
Gómez Delgado, Francisco
Alcalá Díaz, Juan Francisco
Yubero-Serrano, Elena M.
Marín, Carmen
Pérez-Caballero, Ana I.
Fuentes-Jiménez, Francisco J.
Rodríguez-Cantalejo, Fernando
Tinahones, Francisco J.
Ordovás, José María
Pérez-Jiménez, Francisco
Pérez-Martínez, Pablo
López-Miranda, José
Camargo García, A.
Publisher
Public Library of ScienceDate
2016Subject
CORDIOPREVIntervention studies
METS:
Mostrar el registro METSPREMIS:
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Show full item recordAbstract
Background
Recent data suggest that the presence of associated metabolic abnormalities may be
important modifiers of the association of obesity with a poorer prognosis in coronary heart
disease. We determined the influence of isolated overweight and obesity on carotid intima
media thickness (IMT-CC), and also assessed whether this influence was determined by
the presence of metabolic abnormalities.
Methods
1002 participants from the CordioPrev study were studied at entry. We determined their
metabolic phenotypes and performed carotid ultrasound assessment. We evaluated the
influence of obesity, overweight and metabolic phenotypes on the IMT-CC.
Results
Metabolically sick participants (defined by the presence of two or more metabolic abnormalities)
showed a greater IMT-CC than metabolically healthy individuals (p = 4 * 10−6). Overweight
and normal weight patients who were metabolically healthy showed a lower IMT-CC
than the metabolically abnormal groups (all p<0.05). When we evaluated only body weight
(without considering metabolic phenotypes), overweight or obese patients did not differsignificantly from normal-weight patients in their IMT-CC (p = 0.077). However, obesity was
a determinant of IMT-CC when compared to the composite group of normal weight and
overweight patients (all not obese).
Conclusions
In coronary patients, a metabolically abnormal phenotype is associated with a greater IMTCC,
and may be linked to a higher risk of suffering new cardiovascular events. The protection
conferred in the IMT-CC by the absence of metabolic abnormality may be blunted by
the presence of obesity
Fuente
PLoS ONE 11(4): e0153096 (2016)Versión del Editor
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