Serum Collagen Type II Cleavage Epitope and Serum Hyaluronic Acid as Biomarkers for Treatment Monitoring of Dogs with Hip Osteoarthritis
Autor
Vilar, José M.
Rubio, Mónica
Spinella, Giuseppe
Cuervo, Belén
Sopena, Joaquín
Cugat, Ramón
García-Balletbó, Montserrat
Domínguez Pérez, Juan Manuel
Granados, María
Tvarijonaviciute, Asta
Ceron, José J.
Carrilo, José M.
Editor
Public Library of ScienceFecha
2016Materia
DogsOsteoarthritis
Clinical study
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The aim of this study was to evaluate the use of serum type II collagen cleavage epitope
and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs.
For this purpose, a treatment model based on mesenchymal stem cells derived from adipose
tissue combined with plasma rich in growth factors was used. This clinical study
included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline,
just before applying the treatment, and 1, 3, and 6 months after treatment. These results
were compared with those obtained from force plate analysis using the same animals during
the same study period. Levels of type II collagen cleavage epitope decreased and those of
hyaluronic acid increased with clinical improvement objectively verified via force plate analysis,
suggesting these two biomarkers could be effective as indicators of clinical development
of joint disease in dogs.
Introduction