Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations
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Author
Pérez-Caballero, Ana I.
García-Ríos, Antonio
Gómez-Luna, María J.
Gómez-Luna, Purificación
Dembinska-Kiec, Aldona
Rodríguez-Cantalejo, Fernando
Camargo García, A.
Marín, Carmen
Pérez-Martínez, Pablo
Delgado-Lista, Javier
Yubero-Serrano, Elena M.
Tinahones, Francisco J.
Pérez-Jiménez, Francisco
Roche, Helen M.
López-Miranda, José
Publisher
Public Library Of Science (PLOS)Date
2012Subject
Lipid metabolismGene expression
rs7903146 variation
METS:
Mostrar el registro METSPREMIS:
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Show full item recordAbstract
Background: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked
to higher cardiovascular risk. To date, there is little information about the additional impact of this single nucleotide
polymorphism (SNP) beyond glucose metabolism.
Methodology/Principal Findings: We studied whether rs7903146 influenced postprandial lipid metabolism in three
different populations (healthy young men, metabolic syndrome (MetS) patients and elderly persons). Eighty-eight healthy
males were submitted to a single saturated fatty acid-rich test meal. Additionally, 110 middle-aged MetS patients and 20
healthy elderly persons ($65 years) were submitted to three different dietary models followed by test meals. Minor allele
homozygotes for rs7903146 showed a worse postprandial lipemia profile in young males, as seen by a lower HDLcholesterol
and Apo A1 concentration during the postprandial lipemia and a trend towards higher triglycerides (TG), than
the other genotypes. In healthy elderly persons, carriers of the minor allele showed higher total cholesterol, LDL-cholesterol,
Apo B and TG in the fasting state, and a higher postprandial area under the curve for total cholesterol, Apo B, smalltriglyceride
rich lipoprotein (TRL) cholesterol and small-(TRL) triglycerides. These results were accompanied by differential
changes in adipokines. We did not observe any influence of rs7903146 on the postprandium of MetS patients.
Conclusions/Significance: Healthy young males and elderly persons who are carriers of the mutant allele for rs7903146
have an impaired postprandial lipid metabolism that may be mediated by an alteration in adipokine regulation, and may be
related to the higher cardiovascular risk observed in these persons.