Now showing items 1-3 of 3

    • In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features 

      Ibáñez-Costa, Alejandro; Gahete Ortiz, Manuel D.; Rivero-Cortés, Esther; Rincón-Fernández, David; Nelson, Richard; Beltrán, Manuel; Riva, Andrés de la; Japón, Miguel A.; Venegas-Moreno, Eva; García-Arnés, Juan A.; Soto-Moreno, Alfonso; Morgan, Jennifer; Tsomaia, Natia; Culler, Michael D.; Diéguez, Carlos; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2015)
      Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin ...
    • Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly 

      Martín, Juan Francisco; Muñoz-Bravo, José L.; Ibáñez-Costa, Alejandro; Fernández-Maza, Laura; Balcerzyk, Marcin; Leal Campanario, Rocío; Luque, Raúl M.; Castaño, Justo P.; Venegas-Moreno, Eva; Soto-Moreno, Alfonso; Leal-Cerro, Alfonso; Cano, David A. (Nature Research, 2015)
      Acromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by pituitary adenomas. Elevated GH and IGF-I levels ...
    • Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer 

      Gómez-Gómez, E.; Jiménez-Vacas, J.M.; Pedraza-Arévalo, Sergio; López-López, F.; Herrero-Aguayo, V.; Hormaechea Agulla, Daniel; Valero-Rosa, J.; Ibáñez-Costa, Alejandro; León González, A.J.; Sánchez-Sánchez, Rafael; Gónzalez Serrano, T.; Requena-Tapia, M.J.; Castaño, Justo P.; Carrasco-Valiente, J.; Gahete Ortiz, Manuel D.; Luque, R.M. (MDPI, 2019)
      Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the ...