Departamento de Química Agrícola, Edafología y Microbiologíahttp://hdl.handle.net/10396/3482024-03-28T09:14:53Z2024-03-28T09:14:53ZExtended-spectrum β-lactamase-producing and carbapenem-resistant Enterobacterales bloodstream infection after solid organ transplantation: Recent trends in epidemiology and therapeutic approachesPérez-Nadales, ElenaFernández Ruiz, MarioGutiérrez Gutiérrez, BelénPascual, ÁlvaroRodríguez Baño, JesúsMartínez-Martínez, LuisAguado, José MaríaTorre-Cisneros, Julián de lahttp://hdl.handle.net/10396/276402024-03-08T03:00:45Z2022-01-01T00:00:00ZExtended-spectrum β-lactamase-producing and carbapenem-resistant Enterobacterales bloodstream infection after solid organ transplantation: Recent trends in epidemiology and therapeutic approaches
Pérez-Nadales, Elena; Fernández Ruiz, Mario; Gutiérrez Gutiérrez, Belén; Pascual, Álvaro; Rodríguez Baño, Jesús; Martínez-Martínez, Luis; Aguado, José María; Torre-Cisneros, Julián de la
Background
Infections caused by multidrug-resistant gram-negative bacilli (MDR GNB), in particular extended-spectrum β-lactamase-producing (ESBL-E) and carbapenem-resistant Enterobacterales (CRE), pose a major threat in solid organ transplantation (SOT). Outcome prediction and therapy are challenging due to the scarcity of randomized clinical trials (RCTs) or well-designed observational studies focused on this population.
Methods
Narrative review with a focus on the contributions provided by the ongoing multinational INCREMENT-SOT consortium (ClinicalTrials identifier NCT02852902) in the fields of epidemiology and clinical management.
Results
The Spanish Society of Transplantation (SET), the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC), and the Spanish Network for Research in Infectious Diseases (REIPI) recently published their recommendations for the management of MDR GNB infections in SOT recipients. We revisit the SET/GESITRA-SEIMC/REIPI document taking into consideration new evidence that emerged on the molecular epidemiology, prognostic stratification, and treatment of post-transplant ESBL-E and CRE infections. Results derived from the INCREMENT-SOT consortium may support the therapeutic approach to post-transplant bloodstream infection (BSI). The initiatives devoted to sparing the use of carbapenems in low-risk ESBL-E BSI or to repurposing existing non-β-lactam antibiotics for CRE in both non-transplant and transplant patients are reviewed, as well as the eventual positioning in the specific SOT setting of recently approved antibiotics.
Conclusion
Due to the clinical complexity and relative rarity of ESBL-E and CRE infections in SOT recipients, multinational cooperative efforts such as the INCREMENT-SOT Project should be encouraged. In addition, RCTs focused on post-transplant serious infection remain urgently needed.
2022-01-01T00:00:00ZGlycerol photoreforming for photocatalytic hydrogen production on binary and ternary Pt-g-C3N4-TiO2 systems: a comparative studyHerrera-Beurnio, M. CarmenLópez-Tenllado, Francisco J.Hidalgo-Carrillo, J.Martín-Gómez, JuanEstévez, R.Urbano, Francisco JoséMarinas, Albertohttp://hdl.handle.net/10396/274562024-03-21T10:56:26Z2024-01-01T00:00:00ZGlycerol photoreforming for photocatalytic hydrogen production on binary and ternary Pt-g-C3N4-TiO2 systems: a comparative study
Herrera-Beurnio, M. Carmen; López-Tenllado, Francisco J.; Hidalgo-Carrillo, J.; Martín-Gómez, Juan; Estévez, R.; Urbano, Francisco José; Marinas, Alberto
Photocatalytic hydrogen production using two sacrificial agents (triethanolamine and glycerol) was conducted on several binary (Pt/TiO2 and Pt/g-C3N4) and ternary systems (Pt on a heterojunction between TiO2 and g-C3N4 (Pt/(g-C3N4-TiO2) and on a physical mixture of semiconductors (Pt/(TiO2 +g-C3N4)). Reactions were carried out under visible light (450 nm) and UV (365 nm) radiation, from 10% (v/v) and 0.5% (v/v) sacrificial agent aqueous solutions, hydrogen production values being ca- 2–3 times greater in the former case. For visible light, the heterojunction was the most active system using triethanolamine whereas Pt/TiO2 system and glycerol was the best option under UV radiation. All in all, the highest hydrogen production value from a 10% (v/v) glycerol in water solution was on Pt/TiO2 (named Ptuv/Ti), under UV light, yielding around 165 mmol H2·gcat−1·after 6 h (that is, ca. 27.5 mmol·gcat−1·h−1). Hydrogen photoproduction studies from glyceraldehyde, dihydroxyacetone, and glycerol either alone or in binary mixtures (i.e., competitive reactions) cast further light on the glycerol reaction mechanism. Results evidenced that the adsorption strength on the catalysts follows the sequence glyceraldehyde > dihydroxyacetone > glycerol, adsorption of the former being particularly high on the heterojunction. Reactions were ca. twice as fast on Pt/TiO2 as on the Pt/(g-C3N4-TiO2) heterojunction and even though initial stages of the mechanism seems to differ a bit for the semiconductors, there is a hydrogen production value from which mechanism is apparently the same on both solids.
2024-01-01T00:00:00ZAn IoT barrel bung to monitor evolution wine elaborated under biological agingCañete-Carmona, EduardoGallego-Martínez, Juan-JoséYousef-Jiménez, LailaRuiz Flores, AlbertoGersnoviez, AndrésMoreno, Juanhttp://hdl.handle.net/10396/272782024-02-19T11:15:51Z2022-01-01T00:00:00ZAn IoT barrel bung to monitor evolution wine elaborated under biological aging
Cañete-Carmona, Eduardo; Gallego-Martínez, Juan-José; Yousef-Jiménez, Laila; Ruiz Flores, Alberto; Gersnoviez, Andrés; Moreno, Juan
Wine aging is a crucial step in the elaboration of special and high quality wines as the sherry and
like-sherry type wines are. Some of these wines remain in oak barrels during a long time period,
subjected to the “biological aging” process, which is characterized by the maintenance of a yeast
biofilm over the wine surface. This yeast´s layer protects the wine from the oxidation and contribute
to its specific organoleptic characteristics. This work shows an instrumented bung for monitoring a set
of parameters to control this wine aging process. Tests carried out in a winery over 5 months, under
real conditions, prove that this device is capable of monitoring key parameters of wine subjected to
biological aging in a wireless way, working autonomously for more than a year.
2022-01-01T00:00:00ZMetabolomics of red wines aged traditionally, with chips or stavesDumitriu, Georgina-DianaSánchez-Suárez, FernandoPeinado, Rafael A.Cotea, Valeriu V.López de Lerma Extremera, M. NievesGabur, IulianSimioniuc, Violetahttp://hdl.handle.net/10396/265752024-01-26T02:39:20Z2024-01-01T00:00:00ZMetabolomics of red wines aged traditionally, with chips or staves
Dumitriu, Georgina-Diana; Sánchez-Suárez, Fernando; Peinado, Rafael A.; Cotea, Valeriu V.; López de Lerma Extremera, M. Nieves; Gabur, Iulian; Simioniuc, Violeta
Traditionally and alternatively aged wines’ odour activity values (OAVs) are investigated to differentiate and highlight the differences between the selected methods. An analysis of the volatile aroma compounds of wines derived from ageing in barrels, oak chips, and staves was performed using stir bar sorptive extraction chromatography–mass spectroscopy (SBSE-GC-MS). The results showed that alcohols, esters, and oak compounds were the main contributors to aroma, and their OAVs were higher in the stave samples after 3 months than in the samples from the other two systems of ageing. Furthermore, wines aged with staves have stronger fruity, spiced, and woody aromas, while samples aged in barrels present more chemistry-driven, floral, caramelly, and creamy aromas. The staves—medium plus toast (SMPT at 3 months > 225) and chips—medium plus toast (CMPT at 3 months > 170) showed the highest levels of aromatic series, suggesting that alternative systems provided more powerful aromas than traditional systems, such as barrels—medium plus toast (BMPT at 3 months > 150). A principal component analysis (PCA), orthogonal partial least squares (OPLS) analysis, and cluster analysis allowed for a clear differentiation to be made between red wines according to ageing systems and ageing times. The odour activity values fingerprint in winemaking is a feasible approach to characterise and distinguish wines. Moreover, OAVs provide important information on the effects of production methods on wine quality and aroma profile.
2024-01-01T00:00:00Z