DEMQ-Artículos, capítulos...
http://hdl.handle.net/10396/2288
2024-03-29T05:12:26ZExtra-Virgin Olive Oil Modifies the Changes Induced in Non-Nervous Organs and Tissues by Experimental Autoimmune Encephalomyelitis Models
http://hdl.handle.net/10396/19034
Extra-Virgin Olive Oil Modifies the Changes Induced in Non-Nervous Organs and Tissues by Experimental Autoimmune Encephalomyelitis Models
Conde, Cristina; Escribano, Begoña M.; Luque, Evelio; Feijóo, Montserrat; Caballero-Villarraso, Javier; Valdelvira, Manuel E.; Ochoa Sepúlveda, Juan J.; Lillo, Rafael; Paz, Elier; Santamaría, Abel; Agüera, Eduardo; Túnez, Isaac
This study reveals the existence of oxidative stress (reactive oxygen species (ROS)) in non-nervous organs and tissues in multiple sclerosis (MS) by means of a model of experimental autoimmune encephalomyelitis (EAE) in rats. This model reproduces a similar situation to MS, as well as its relationship with intestinal microbiota starting from the changes in bacterial lipopolysaccharide levels (LPS) in the outer wall of the gram-negative bacteria. Finally, the administration of extra-virgin olive oil (EVOO), hydroxytirosol (HT), and oleic acid (OA) exert beneficial effects. Twenty-five Dark Agouti two-month-old male rats, weighing around 190 g, were distributed into the following groups: Control, EAE (experimental autoimmune encephalomyelitis group), EAE + EVOO, EAE + HT, and EAE + OA. The glutathione redox system with the EAE was measured in heart, kidney, liver, and small and large intestines. The LPS and the correlation with oxidative stress in the small and large intestines were also investigated. The results showed that (1) the oxidative damage in the EAE model affects non-nervous organs and tissues; (2) The LPS is related to inflammatory phenomena and oxidative stress in the intestinal tissue and in other organs; (3) The administration of EVOO, HT, and OA reduces the LPS levels at the same time as minimizing the oxidative damage; (4) EVOO, HT, and OA improve the disease’s clinical score; and (5) on balance, EVOO offers a better neuroprotective effect.
2019-01-01T00:00:00ZMaterial docente en formato electrónico para la enseñanza de la asignatura de Procedimientos Quirúrgicos en el grado en Medicina
http://hdl.handle.net/10396/16944
Material docente en formato electrónico para la enseñanza de la asignatura de Procedimientos Quirúrgicos en el grado en Medicina
López-Cillero, P.; Rufián Peña, Sebastián; Moreno Casado, Paula; Álvarez Kindelán, Antonio; Luque Molina, Antonio
La Cirugía es la parte de la Medicina que tiene por objeto curar las enfermedades por medio de operaciones hechas con las manos o a través de instrumentos. Hasta ahora, la enseñanza de la asignatura de “Procedimientos Quirúrgicos”, que corresponde a los estudiantes de segundo curso del Grado en Medicina de la Universidad de Córdoba, se ha llevado a cabo según el estilo tradicional. Se ha llevado a cabo un proyecto específico de elaboración de una herramienta multimedia, en concreto, un ebook, con el contenido teórico y práctico de la asignatura de Procedimientos Quirúrgicos, para mejorar la docencia médica según las directrices del Espacio Europeo de Educación Superior (EEES), fomentando así el desarrollo de una educación médica de calidad.; Surgery is the branch of Medicine concerned with diseases and conditions requiring or amenable to operative or manual procedures. To date, teaching the subject of Surgical Procedures for 2nd-year students of the degree of Medicine has been done in a traditional manner. We have developed a specific project, with the creation of a multimedia resource consisting in an ebook with the theoretical and practical content of the Surgical Proceedings subject, in order to improve medical learning following the principles of the European Higher Education Area. This will aid in promoting the development of a high-quality medical teaching.
2018-01-01T00:00:00ZGenome-Wide Expression in Visceral Adipose Tissue from Obese Prepubertal Children
http://hdl.handle.net/10396/15396
Genome-Wide Expression in Visceral Adipose Tissue from Obese Prepubertal Children
Aguilera García, Concepción; Gómez-Llorente, Carolina; Tofé, Inés; Gil Campos, Mercedes; Cañete Estrada, Ramón; Gil, Ángel
Characterization of the genes expressed in adipose tissue (AT) is key to understanding the pathogenesis of obesity and to developing treatments for this condition. Our objective was to compare the gene expression in visceral AT (VAT) between obese and normal-weight prepubertal children. A total of fifteen obese and sixteen normal-weight children undergoing abdominal elective surgery were selected. RNA was extracted from VAT biopsies. Microarray experiments were independently performed for each sample (six obese and five normal-weight samples). Validation by quantitative PCR (qPCR) was performed on an additional 10 obese and 10 normal-weight VAT samples. Of 1276 differentially expressed genes (p < 0.05), 245 were more than two-fold higher in obese children than in normal-weight children. As validated by qPCR, expression was upregulated in genes involved in lipid and amino acid metabolism (CES1, NPRR3 and BHMT2), oxidative stress and extracellular matrix regulation (TNMD and NQO1), adipogenesis (CRYAB and AFF1) and inflammation (ANXA1); by contrast, only CALCRL gene expression was confirmed to be downregulated. In conclusion, this study in prepubertal children demonstrates the up- and down-regulation of genes that encode molecules that were previously proposed to influence the pathogenesis of adulthood obesity, as well as previously unreported dysregulated genes that may be candidate genes in the aetiology of obesity.
2015-01-01T00:00:00ZLumbalgia durante la práctica del windsurfing
http://hdl.handle.net/10396/10954
Lumbalgia durante la práctica del windsurfing
Carpintero Benítez, Pedro; García Criado, Emilio; López Castro, Pedro; Morales Jiménez, Rafael; Entrenas Aumente, Rafael; García-Frasquet, Ángeles; Baena Mansilla, Paulino
El windsurfing es, posiblemente, el deporte náutico más practicado hoy en el mundo. Pero tiene un aspecto
negativo: las lesiones que provoca. Existe poca experiencia al respecto y la información no es abundante. Por
estas razones, los autores realizaron una encuesta clínica a 55 personas que pratican este deporte para
comprobar la incidencia de tales afecciones, especialmente de la lumbalgia, así como las razones de su
presentación, muy frecuente entre ellos. Hallaron que el 66 % habían padecido dolor lumbar después de su
práctica. Concluyen que la adopción de una postura incorrecta, motivada por el poco dominio de la técnica, el
no poseer una buena preparación física previa y no efectuar un calentamiento muscular antes de cada sesión,
constituyen las principales causas de las lesiones y molestias musculares causadas por la sobrecarga que
debe enfrentar el sistema muscular, especialmente la región lumbar
1996-01-01T00:00:00Z