http://hdl.handle.net/10396/2280 Sun, 12 Apr 2026 08:51:21 GMT 2026-04-12T08:51:21Z http://hdl.handle.net/10396/33356 Elevated melatonin levels in natalizumab-treated female patients with relapsing-remitting multiple sclerosis: Relationship to oxidative stress Bahamonde, Carmen; Conde, Cristina; Agüera, Eduardo; Lillo, Rafael; Luque, Evelio; Gascón, Félix; Feijóo, Montserrat; Cruz, Antonio H; Sánchez-López, Fernando; Túnez, Isaac Natalizumab is currently the most successful clinical treatment for multiple sclerosis. The use of this drug is associated with the reduction in the number of relapses and a slowing in disease progression, as well as an improvement in signs and symptoms displayed by the patients. To evaluate the effect of natalizumab on melatonin and its relationship with peripheral oxidative damage, we studied the serum melatonin levels in 18 patients with relapsing-remitting multiple sclerosis. Natalizumab caused significant increases in serum melatonin concentrations. This change was associated with a rise in increase of antioxidants and a reduction in oxidative stress biomarkers. In conclusion, these data may explain, at least in part, some of the beneficial effects exhibited by disease antibody such as its antioxidant capacity. Embargado hasta 01/01/2100. Wed, 01 Jan 2014 00:00:00 GMT http://hdl.handle.net/10396/33356 2014-01-01T00:00:00Z http://hdl.handle.net/10396/29774 A signature of circulating microRNAs predicts the response to treatment with FOLFIRI plus aflibercept in metastatic colorectal cancer patients Toledano-Fonseca, Marta; Gómez-España, M. Auxiliadora; Élez, E.; Grávalos, C.; García-Alfonso, P.; Rodríguez, R.; Losa, F.; Alés Díaz, I.; Dopico Graña, Miguel; Valladares-Ayerbes, Manuel; García-Ortiz, M.V.; Polo, E.; Salgado, M.; Rivera, Fernando; Safont, M. J.; Salud, A.; Ruiz-Casado, A.; Tabernero, J. M.; Riesco, M. C.; Rodríguez-Ariza, Antonio; Aranda Aguilar, Enrique The benefit of adding the antiangiogenic drug aflibercept to FOLFIRI regime in metastatic colorectal cancer (CRC) patients resistant to or progressive on an oxaliplatin-based therapy has been previously demonstrated. However, the absence of validated biomarkers to predict greater outcomes is a major challenge encountered when using antiangiogenic therapies. In this study we investigated profiles of circulating microRNAs (miRNAs) to build predictive models of response to treatment and survival. Plasma was obtained from 98 metastatic CRC patients enrolled in a clinical phase II trial before receiving FOLFIRI plus aflibercept treatment, and the circulating levels of 754 individual miRNAs were quantified using real-time PCR. A distinct signature of circulating miRNAs differentiated responder from non-responder patients. Remarkably, most of these miRNAs were found to target genes that are involved in angiogenic processes. Accordingly, some of these miRNAs had predictive value and entered in predictive models of response to therapy, progression of disease, and survival of patients treated with FOLFIRI plus aflibercept. Among these miRNAs, circulating levels of hsa-miR-33b-5p efficiently discriminated between responder and non-responder patients and predicted the risk of disease progression. Moreover, the combination of circulating VEGF-A and miR-33b-5p levels improved clinical stratification of metastatic CRC patients who were to receive FOLFIRI plus aflibercept treatment. In conclusion, our study supports circulating miRNAs as valuable biomarkers for predicting better outcomes in metastatic CRC patients treated with FOLFIRI plus aflibercept. Sun, 01 Jan 2023 00:00:00 GMT http://hdl.handle.net/10396/29774 2023-01-01T00:00:00Z http://hdl.handle.net/10396/19034 Extra-Virgin Olive Oil Modifies the Changes Induced in Non-Nervous Organs and Tissues by Experimental Autoimmune Encephalomyelitis Models Conde, Cristina; Escribano, Begoña M.; Luque, Evelio; Feijóo, Montserrat; Caballero-Villarraso, Javier; Valdelvira, Manuel E.; Ochoa Sepúlveda, Juan J.; Lillo, Rafael; Paz, Elier; Santamaría, Abel; Agüera, Eduardo; Túnez, Isaac This study reveals the existence of oxidative stress (reactive oxygen species (ROS)) in non-nervous organs and tissues in multiple sclerosis (MS) by means of a model of experimental autoimmune encephalomyelitis (EAE) in rats. This model reproduces a similar situation to MS, as well as its relationship with intestinal microbiota starting from the changes in bacterial lipopolysaccharide levels (LPS) in the outer wall of the gram-negative bacteria. Finally, the administration of extra-virgin olive oil (EVOO), hydroxytirosol (HT), and oleic acid (OA) exert beneficial effects. Twenty-five Dark Agouti two-month-old male rats, weighing around 190 g, were distributed into the following groups: Control, EAE (experimental autoimmune encephalomyelitis group), EAE + EVOO, EAE + HT, and EAE + OA. The glutathione redox system with the EAE was measured in heart, kidney, liver, and small and large intestines. The LPS and the correlation with oxidative stress in the small and large intestines were also investigated. The results showed that (1) the oxidative damage in the EAE model affects non-nervous organs and tissues; (2) The LPS is related to inflammatory phenomena and oxidative stress in the intestinal tissue and in other organs; (3) The administration of EVOO, HT, and OA reduces the LPS levels at the same time as minimizing the oxidative damage; (4) EVOO, HT, and OA improve the disease’s clinical score; and (5) on balance, EVOO offers a better neuroprotective effect. Tue, 01 Jan 2019 00:00:00 GMT http://hdl.handle.net/10396/19034 2019-01-01T00:00:00Z http://hdl.handle.net/10396/18290 Guía UCO para la elaboración y evaluación de un TFG: análisis de problemas y propuesta sincrética de soluciones Rodríguez Tapia, Sergio; Jaén-Moreno, M. J.; García Ramos, Mª Dolores; Jacinto García, Eduardo José El presente proyecto surge para dar respuesta a una serie de problemas que se dan durante el proceso de elaboración y defensa de los Trabajos Fin de Grado en el marco de la Universidad de Córdoba. A pesar de que actualmente existen esfuerzos por mejorar los criterios aplicados en los distintos centros de la UCO, se ha podido comprobar una falta de uniformidad en las guías y en las recomendaciones ligadas a la realización de los TFG, algo que, salvando la comprensible adecuación a las características de cada área, puede suponer un riesgo para la consecución de un sistema de evaluación justo. Además, algunas facultades carecen de criterios públicos de evaluación, lo que puede dar lugar a situaciones arbitrarias o irregulares. Para ello, en primer lugar, se ha analizado la opinión de profesorado y alumnado con respecto al TFG. Con el fin de resolver las deficiencias encontradas, se ha propuesto una solución que englobe todos los centros que forman la UCO: una herramienta que contemple las competencias básicas reconocidas por la legislación actual, comunes a todos los grados, y que tengan naturaleza transdisciplinar, para, a partir de ahí, poder construir un sistema de evaluación más razonable, coherente y uniforme para toda la Universidad de Córdoba.; The present project mains to solve a series of problems that occur during the process of preparation and defence of the undergraduate final dissertation (TFG) within the University of Córdoba. Although there are currently efforts to improve the criteria applied in the different centres of the UCO, it has been possible to verify a lack of uniformity in the guides and in the recommendations related to the realization of the TFG, something that, beyond the understandable adaptation to the characteristics of each area, may pose a risk to the achievement of a fair evaluation system. In addition, some faculties lack public evaluation criteria, which may give rise to arbitrary or irregular situations. To do this, first of all, the opinion of teachers and students regarding the TFG has been analysed. In order to solve the deficiencies found, a solution has been proposed that encompasses all the centres that make up the UCO: a scale that contemplates the basic competences recognized by the current legislation, common to all grades, and of a transdisciplinary nature to be able to build a more reasonable, coherent and uniform evaluation system for the entire University of Córdoba. Mon, 01 Jan 2018 00:00:00 GMT http://hdl.handle.net/10396/18290 2018-01-01T00:00:00Z