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Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease
(MDPI, 2020)
Fibroblast Growth Factor 23 (FGF23) and Klotho play an essential role in the regulation of mineral metabolism, and both are altered as a consequence of renal failure. FGF23 increases to augment phosphaturia, which prevents ...
Nuclear Translocation of b-Catenin during Mesenchymal Stem Cells Differentiation into Hepatocytes Is Associated with a Tumoral Phenotype
(Public Libray of Science (PLOS), 2012)
Wnt/b-catenin pathway controls biochemical processes related to cell differentiation. In committed cells the alteration of
this pathway has been associated with tumors as hepatocellular carcinoma or hepatoblastoma. The ...
Magnesium Inhibits Wnt/β-Catenin Activity and Reverses the Osteogenic Transformation of Vascular Smooth Muscle Cells
(Public Library of Science, 2014)
Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly increased magnesium levels and aimed at determining: a) whether ...
TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways
(Public Library of Science, 2014)
Background: Transforming growth factor-b (TGF-b) is a key cytokine during differentiation of mesenchymal stem cells (MSC)
into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of ...
Magnesium Replacement to Protect Cardiovascular and Kidney Damage? Lack of Prospective Clinical Trials
(MDPI, 2018)
Patients with advanced chronic kidney disease exhibit an increase in cardiovascular
mortality. Recent works have shown that low levels of magnesium are associated with increased
cardiovascular and all-cause mortality in ...
In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation
(American Journal of Physiology, 2012)
The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells calcification in vitro. Human vascular smooth muscle cells were ...
Uremic toxins induce THP-1 Monocyte endothelial adhesion and migration through specific miRNA expression
(MDPI, 2023)
Atherosclerosis is initiated by the activation of endothelial cells that allows monocyte adhesion and transmigration through the vascular wall. The accumulation of uremic toxins such as indoxyl sulphate (IS) and p-cresol ...
Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
(MDPI, 2023)
whether a dietary Mg supplementation might attenuate vascular dysfunction through the modulation of oxidative stress and inflammation in concurrent MetS and CKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 ...