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Hallmarks of aging in kidney from mice submitted to genetic and nutritional intervention
(Universidad de Córdoba, UCOPress, 2020)
Aging should be considered as a multifactorial phenomenon and, consequently, its study should be addressed through different experimental designs. This includes nutritional and genetic interventions. In addition, it is ...
Marcadores inmunológicos predictores de evolución del trasplante
(Universidad de Córdoba, UCOPress, 2020)
Antecedentes. La alorrespuesta humoral, particularmente la mediada por la presencia de anticuerpos frente a los antígenos leucocitarios humanos (HLA) del aloinjerto, se asocia a un incremento en la prevalencia de rechazo ...
Interacción entre la función reproductiva y metabólica: caracterización del papel de factores neuroendocrinos y el sensor energético, proteína quinasa activada por AMP (AMPK)
(Universidad de Córdoba, UCOPress, 2020)
La reproducción es un proceso costoso en términos de consumo energético que, si bien es esencial para la supervivencia de las especies, es prescindible a nivel individual. Por lo tanto, la maduración y la función del eje ...
Identification of novel molecular markers and contribution of splicing mechanisms in endocrine-related tumoral pathologies
(Universidad de Córdoba, UCOPress, 2020)
Cancer represents one of the main challenges for the human being, in that it encompasses some of the most severe and health-threatening pathologies worldwide. Although great efforts are being implemented and significant ...
Non psychotropic cannabinoids for the treatment of inflammatory diseases
(Universidad de Córdoba, UCOPress, 2020)
Medicinal cannabis and purified cannabinoids have garnered worldwide attention since millions of patients can benefit from their medical properties. Over the past few years, the endocannabinoid system (ECS) has emerged as ...
Estudio del Cannabidiol, Estrigolactonas y otros productos naturales sobre diferentes dianas farmacológicas en dermatología. Desarrollo de nuevos productos de uso tópico
(Universidad de Córdoba, UCOPress, 2020)
Las afecciones dermatológicas como la dermatitis atópica, el acné, trastornos de hiperpigmentación o la psoriasis presentan una elevada prevalencia en la sociedad. Para los casos más severos se suele recurrir a fármacos ...
Caracterización de nuevas rutas reguladoras del metabolismo lipídico en adipocitos. Alteraciones en obesidad
(Universidad de Córdoba, UCOPress, 2020)
Identification of novel endocrine-metabolic and splicing machinery factors with diagnostic, prognostic and/or therapeutic potential in prostate cancer
(Universidad de Córdoba, UCOPress, 2020)
Prostate cancer (PCa) is the tumor pathology with the highest incidence among men in developed countries and represents one of the main causes of cancer-related death in this group. Despite the advances achieved during the ...
Mediators of the cellular response to the development of obesity and metabolic disease
(Universidad de Córdoba, UCOPress, 2021)
Obesity is the pandemic of the 21st century. Overall, about 15% of the world’s adult population is obese, and if the rising trend continues, it is estimated that global prevalence reaches 20% by 2025. Obesity poses a major ...
Analysis of the roles of kisspeptins and the tachykinin receptor, Tacr2, in the control of Reproduction: novel interactive pathways, regulatory mechanisms and metabolic implications
(Universidad de Córdoba, UCOPress, 2021)
For sake of clarity, this Doctoral Thesis has been divided in 3 main experimental sets: In the Experimental Set 1, a comprehensive series of phenotypical, pharmacological, behavioral and histological analyses were conducted ...