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dc.contributor.authorMuñoz-Castañeda, Juan R.
dc.contributor.authorPendón-Ruiz de Mier, María V.
dc.contributor.authorRodríguez, Mariano
dc.contributor.authorRodríguez-Ortiz, Maria E.
dc.date.accessioned2018-11-02T13:41:17Z
dc.date.available2018-11-02T13:41:17Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10396/17427
dc.description.abstractPatients with advanced chronic kidney disease exhibit an increase in cardiovascular mortality. Recent works have shown that low levels of magnesium are associated with increased cardiovascular and all-cause mortality in hemodialysis patients. Epidemiological studies suggest an influence of low levels of magnesium on the occurrence of cardiovascular disease, which is also observed in the normal population. Magnesium is involved in critical cellular events such as apoptosis and oxidative stress. It also participates in a number of enzymatic reactions. In animal models of uremia, dietary supplementation of magnesium reduces vascular calcifications and mortality; in vitro, an increase of magnesium concentration decreases osteogenic transdifferentiation of vascular smooth muscle cells. Therefore, it may be appropriate to evaluate whether magnesium replacement should be administered in an attempt to reduce vascular damage and mortality in the uremic population In the present manuscript, we will review the magnesium homeostasis, the involvement of magnesium in enzymatic reactions, apoptosis and oxidative stress and the clinical association between magnesium and cardiovascular disease in the general population and in the context of chronic kidney disease. We will also analyze the role of magnesium on kidney function. Finally, the experimental evidence of the beneficial effects of magnesium replacement in chronic kidney disease will be thoroughly describedes_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceInternational Journal of Molecular Sciences 19, 664 (2018)es_ES
dc.subjectMagnesiumes_ES
dc.subjectChronic kidney diseasees_ES
dc.subjectCardiovascular diseasees_ES
dc.subjectVascular calcificationes_ES
dc.subjectMortalityes_ES
dc.titleMagnesium Replacement to Protect Cardiovascular and Kidney Damage? Lack of Prospective Clinical Trialses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/ijms19030664es_ES
dc.relation.projectIDJunta de Andalucía. PI14/0638es_ES
dc.relation.projectIDJunta de Andalucía. PI17/01010es_ES
dc.relation.projectIDJunta de Andalucía. PI-154-2017es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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