Treatment of canine leishmaniasis with marbofloxacin in dogs with renal disease
Autor
Pineda Martos, Carmen María
Aguilera Tejero, Escolástico
Morales, María C.
Belinchón-Lorenzo, Silvia
Gómez-Nieto, Luis C.
García, Pablo
Martínez-Moreno, Julio M.
Rodríguez-Ortiz, Maria E.
López, Ignacio
Editor
Public Library of ScienceFecha
2017Materia
Canine leishmaniasisCanL
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Treatment of canine leishmaniasis (CanL) represents a challenge. Due to the high prevalence
of renal disease associated to CanL, it is important to find an effective drug that does
not damage the kidneys. Marbofloxacin has been shown to be effective and well tolerated in
non-azotemic dogs with leishmaniasis. To evaluate the safety and efficacy of marbofloxacin
in dogs with leishmaniasis and decreased renal function, 28 dogs suffering from leishmaniasis
and chronic kidney disease (CKD) were treated with oral marbofloxacin at 2 mg/Kg/day
for 28 days. During treatment dogs were assessed by performing weekly physical exams,
measuring blood pressure and evaluating blood and urine parameters. Lymph node aspirations
were also obtained at days 0 and 28. The global clinical score decreased significantly,
from 6.2±3.4 to 4.7±3.1 (p = 0.0001), after treatment. Marbofloxacin also decreased parasitic
load in 72% of the dogs. No significant differences in plasma creatinine, urine specific
gravity, urinary concentrations of cystatin C, ferritin and urinary protein loss were detected
during treatment. A transient but significant decrease in blood pressure was detected up to
day 14 (from 180.1±36.6 to 166.0±32.7 mmHg; p = 0.016). Moreover, dogs showed a significant
increase in plasma albumin concentration (from 15.0±5.2 to 16.6±3.9 g/L; p = 0.014)
and a significant decrease in globulin concentration (from 59.0±18.1 to 54.1±18.0 g/L; p =
0.005). The results demonstrate that, in addition to being effective for treatment of CanL,
marbofloxacin is a very safe drug in dogs with CKD and leishmaniasis.