Evaluation of the GenoType Mycobacteria Direct Assay for Detection of Mycobacterium tuberculosis Complex and Four Atypical Mycobacterial Species in Clinical Samples
Franco Alvárez de Luna, Francisco
Casal Román, Manuel
PublisherAmerican Society for Microbilogy
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We evaluated GenoType Mycobacteria Direct (GTMD), a novel commercial assay based on nucleic acid sequence-based amplification technology, for the detection of Mycobacterium tuberculosis complex, M. avium, M. intracellulare, M. kansasii, and M. malmoense directly from clinical specimens. A total of 134 respiratory and extrapulmonary samples from 65 patients were processed. Sensitivity, specificity, positive predictive, and negative predictive values for GTMD were 92, 100, 100, and 77%, respectively. The GMTD technique is useful, reliable, and rapid when used during the normal routine of a clinical laboratory.