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dc.contributor.authorFuster, M.G.
dc.contributor.authorMontalbán, M.G.
dc.contributor.authorCarissimi, G.
dc.contributor.authorLima, B.
dc.contributor.authorFeresin, G.E.
dc.contributor.authorCano Luna, Manuel
dc.contributor.authorGiner-Casares, Juan J.
dc.contributor.authorLópez-Cascales, J.J.
dc.contributor.authorEnriz, R.D.
dc.contributor.authorVíllora, G.
dc.date.accessioned2021-01-13T12:43:19Z
dc.date.available2021-01-13T12:43:19Z
dc.date.issued2020
dc.identifier.urihttp://hdl.handle.net/10396/20969
dc.description.abstractPathogenic bacteria have the ability to develop antibiotic resistance mechanisms. Their action consists mainly in the production of bacterial enzymes that inactivate antibiotics or the appearance of modifications that prevent the arrival of the drug at the target point or the alteration of the target point itself, becoming a growing problem for health systems. Chitosan–gold nanoparticles (Cs-AuNPs) have been shown as effective bactericidal materials avoiding damage to human cells. In this work, Cs-AuNPs were synthesized using chitosan as the reducing agent, and a systematic analysis of the influence of the synthesis parameters on the size and zeta potential of the Cs-AuNPs and their UV-vis spectra was carried out. We used a simulation model to characterize the interaction of chitosan with bacterial membranes, using a symmetric charged bilayer and two different chitosan models with different degrees of the chitosan amine protonation as a function of pH, with the aim to elucidate the antibacterial mechanism involving the cell wall disruption. The Cs-AuNP antibacterial activity was evaluated to check the simulation model.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceNanomaterials 10(12), 2340 (2020)es_ES
dc.subjectChitosan-gold nanoparticlees_ES
dc.subjectAntimicrobial activityes_ES
dc.subjectComputational modeles_ES
dc.titleAntibacterial E ect of Chitosan–Gold Nanoparticles and Computational Modeling of the Interaction between Chitosan and a Lipid Bilayer Modeles_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/nano10122340es_ES
dc.relation.projectIDGobierno de España. CTQ2017-87708-Res_ES
dc.relation.projectIDGobierno de España. CTQ2017-83961-Res_ES
dc.relation.projectIDGobierno de España. CTQ2017-92264-EXPes_ES
dc.relation.projectIDGobierno de España. RyC-2014-14956es_ES
dc.relation.projectIDGobierno de España. PRE2018-086441es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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