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dc.contributor.authorCasado‐Díaz, Antonio
dc.contributor.authorRodríguez Ramos, Ángel
dc.contributor.authorTorrecillas‐Baena, Bárbara
dc.contributor.authorDorado, G.
dc.contributor.authorQuesada Gómez, José Manuel
dc.contributor.authorGálvez-Moreno, M. Ángeles
dc.date.accessioned2021-11-23T12:41:30Z
dc.date.available2021-11-23T12:41:30Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10396/22183
dc.description.abstractPhloretin (a flavonoid abundant in apple), has antioxidant, anti-inflammatory, and glucose-transporter inhibitory properties. Thus, it has interesting pharmacological and nutraceutical potential. Bone-marrow mesenchymal stem cells (MSC) have high differentiation capacity, being essential for maintaining homeostasis and regenerative capacity in the organism. Yet, they preferentially differentiate into adipocytes instead of osteoblasts with aging. This has a negative impact on bone turnover, remodeling, and formation. We have evaluated the effects of phloretin on human adipogenesis, analyzing MSC induced to differentiate into adipocytes. Expression of adipogenic genes, as well as genes encoding OPG and RANKL (involved in osteoclastogenesis), protein synthesis, lipid-droplets formation, and apoptosis, were studied. Results showed that 10 and 20 µM phloretin inhibited adipogenesis. This effect was mediated by increasing beta-catenin, as well as increasing apoptosis in adipocytes, at late stages of differentiation. In addition, this chemical increased OPG gene expression and OPG/RANKL ratio in adipocytes. These results suggest that this flavonoid (including phloretin-rich foods) has interesting potential for clinical and regenerative-medicine applications. Thus, such chemicals could be used to counteract obesity and prevent bone-marrow adiposity. That is particularly useful to protect bone mass and treat diseases like osteoporosis, which is an epidemic worldwide.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceNutrients 13(11), 4185 (2021)es_ES
dc.subjectPhloretines_ES
dc.subjectHuman mesenchymal stem cellses_ES
dc.subjectAdipogenesises_ES
dc.subjectObesityes_ES
dc.subjectBonees_ES
dc.titleFlavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cellses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nu13114185es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI15/01857es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI18/01659es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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