• MIND Diet Impact on Multiple Sclerosis Patients: Biochemical Changes after Nutritional Intervention 

  Navarrete-Pérez, Ainoa; Gómez-Melero, Sara; Escribano, Begoña M.; Galvao-Carmona, Alejandro; Conde Gavilán, Cristina; Peña-Toledo, María Ángeles; Villarrubia, Noelia; Villar, Luisa María; Túnez, Isaac; Agüera, Eduardo; Caballero-Villarraso, Javier (MDPI, 2024)

  There is substantial evidence supporting the neuroprotective effects of the MIND diet in neurodegenerative diseases like Parkinson’s and Alzheimer’s. Our aim was to evaluate the impact of a nutritional intervention (NI) ...

• The Protective Effects of an Aged Black Garlic Water Extract on the Prostate 

  Loreta Libero, María; Montero-Hidalgo, Antonio J .; Recinella, Lucía; Luque, Raúl M.; Generali, Daniele; Acquaviva, Alessandra; Orlando, Giustino; Ferrante, Claudio; Menghini, Luigi; Di Simone, Simonetta Cristina; Nilofar, Nilofar; Chiavaroli, Annalisa; Brunetti, Luigi; Leone, Sheila (MDPI, 2024)

  Chronic inflammation is a recognized risk factor for various cancers, including prostate cancer (PCa). We aim to explore the potential protective effects of aged black garlic extract (ABGE) against inflammation-induced ...

• VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways 

  del Rio, Carmen; Cantarero, Irene; Palomares, Belén; Gómez-Cañas, María; Fernández-Ruíz, Javier; Pavicic, Carolina; García-Martín, Adela; Bellido, María Luz; Ortega-Castro, Rafaela; Pérez-Sánchez, Carlos; López-Pedrera, Chary; Appendino, Giovanni; Calzado Canale, Marco Antonio; Muñoz, Eduardo (Wiley, 2018)

  BACKGROUND AND PURPOSE The endocannabinoid system and PPARγ are important targets for the development of novel compounds against fibrotic diseases such as systemic sclerosis (SSc), also called scleroderma. The aim of ...

• EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis 

  García-Martín, Adela; Garrido Rodríguez-Córdoba, Martín; Navarrete, Carmen; Del Río, Carmen; Bellido, María L.; Appendino, Giovanni; Calzado, Marco A; Muñoz, E. (Elsevier, 2018-01-02)

  Systemic sclerosis (SSc) or scleroderma is a chronic multi-organ autoimmune disease characterized by vascular,immunological, and fibrotic abnormalities. The etiology of SSc is unknown, but there is growing evidence that ...

• Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis 

  García-Martín, Adela; Garrido Rodríguez-Córdoba, Martín; Navarrete, Carmen; Caprioglio, Diego; Palomares, Belén; DeMesa, Jim; Rolland, Alain; Appendino, Giovanni; Muñoz, E. (Elsevier, 2019)

  The endocannabinoid system (ECS) may play a role in the pathophysiology of systemic sclerosis (SSc). Cannabinoids acting as dual PPARγ/CB2 agonists, such as VCE-004.8 and Ajulemic acid (AjA), have been shown to alleviate ...

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