• Sporothrix brasiliensis induces a more severe disease associated with sustained Th17 and regulatory T cells responses than Sporothrix schenckii sensu stricto in mice 

  Batista-Duharte, Alexander; Téllez-Martínez, Damiana; Andrade, Roberto Cleverton; Portuondo, Deivys Leandro; Aparecida Jellmayer, Juliana; Polesi, Marisa Campos; Zeppone Carlos, Iracilda (Elsevier, 2018)

  Little is known about the differences in the CD4+ T-cell response induced by Sporothrix schenckii and Sporothrix brasiliensis, the most virulent species that cause sporotrichosis. Here, the helper (Th) and regulatory T ...

• Efficacy and safety of immunological adjuvants. Where is the cut-off? 

  Batista-Duharte, Alexander; Téllez-Martínez, Damiana; Zeppone Carlos, Iracilda (Elsevier, 2018)

  Research over the past several decades has provided insight into the mode of action of adjuvants. However, the main focus of attention has been the efficacy in the induction of protective immunogenicity, while less effort ...

• Enzymatic synthesis of capric acid-rich structured lipids and their effects on mice with high-fat diet-induced obesity 

  Martínez-Galán, Julián Paul; Ontibón-Echeverri, Catalina María; Campos Costa, Mariana; Batista-Duharte, Alexander; Guerso Batista, Vinicius; Mesa, Victoria; Monti, Rubens; Veloso de Paula, Ariel; Martins Baviera, Amanda (Elsevier, 2021)

  The objective of this study was to produce structured lipids (SLs) by enzymatic acidolysis using Rhizopus oryzae lipase covalently immobilized in a low-cost material. Grape seed oil was used to synthesize SLs containing ...

• Antifungal and immunomodulatory activity of a novel cochleate for amphotericin B delivery against Sporothrix schenckii 

  Batista-Duharte, Alexander; Lastre, Miriam; Romeu, Belkis; Portuondo, Deivys Leandro; Téllez-Martínez, Damiana; Manente, Francine Alessandra; Pérez, Oliver; Zeppone Carlos, Iracilda (Elsevier, 2016)

  Introduction: Sporotrichosis is an emergent subcutaneous mycoses caused by species of the Sporothrix schenckii complex. Amphotericin B (AmB) remains the main antifungal drug for the treatment of systemic infections, but ...

• Immunization with recombinant enolase of Sporothrix spp. (rSsEno) confers effective protection against sporotrichosis in mice 

  Portuondo, Deivys Leandro; Dores-Silva, Paulo Roberto; Ferreira, Lucas Souza; De Oliveira, Carlos S.; Téllez-Martínez, Damiana; Marcos, Caroline Maria; De Aguiar Loesch, Maria Luiza; Guzmán, Fanny; Gava, Lisandra M.; Borges, Julio César; Pereira, Sandro Antonio; Batista-Duharte, Alexander; Zeppone Carlos, Iracilda (Springer Nature, 2019)

  In recent years, research has focused on the immunoreactive components of the Sporothrix schenckii cell wall that can be relevant targets for preventive and therapeutic vaccines against sporotrichosis, an emergent worldwide ...

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