Now showing items 1-3 of 3
In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features
Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin ...
Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer
Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the ...
Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly
(Nature Research, 2015)
Acromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by pituitary adenomas. Elevated GH and IGF-I levels ...