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In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features
(Nature.com, 2015)
Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which
would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets.
The ghrelin ...
Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features
(MDPI, 2019)
Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all brain tumors, and most have a sporadic origin. Recent studies suggest that altered alternative splicing and, consequently, appearance of aberrant ...
Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly
(Nature Research, 2015)
Acromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by pituitary adenomas. Elevated GH and IGF-I levels ...