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In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features
(Nature.com, 2015)
Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which
would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets.
The ghrelin ...
Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly
(Nature Research, 2015)
Acromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by pituitary adenomas. Elevated GH and IGF-I levels ...