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Comparative insights of the kisspeptin/kisspeptin receptor system: lessons from non-mammalian vertebrates
(Elsevier, 2012)
Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as ligands of the G protein‐coupled receptor 54 (GPR54; also termed Kiss1R) with ability to suppress tumor metastasis. In late 2003, ...
Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin
(Public Library Of Science (PLOS), 2012)
Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation
of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase ...