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Comparative insights of the kisspeptin/kisspeptin receptor system: lessons from non-mammalian vertebrates
(Elsevier, 2012)
Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as ligands of the G protein‐coupled receptor 54 (GPR54; also termed Kiss1R) with ability to suppress tumor metastasis. In late 2003, ...
Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin
(Public Library Of Science (PLOS), 2012)
Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation
of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase ...
3-Phenylcoumarins as Inhibitors of HIV-1 Replication
(MDPI, 2012)
We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their
anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones
carrying the luciferase gene as reporter. Inhibition ...
Role of SST, CORT and ghrelin, and its receptors at the endocrine pancreas
(Frontiers In..., 2012)
Diseño de una nueva asignatura dirigida al aprendizaje, integración y evaluación de competencias transversales en el grado de Medicina para la aplicación y mejora de su perfil laboral
(Consejo Social de la Universidad de Córdoba, 2012)
La propuesta presenta la creación de una nueva asignatura
en el grado de Medicina: Aplicación Clínica de las Ciencias
Médicas Básicas –cuyo desarrollo ha implicado una
inversión de 6.000 euros– que se imparte en el ...
La ecoinnovación en el sector agroalimentario: ¿qué puede aportar el Campus?
(Campus de Excelencia Internacional Agroalimentario, 2012)
The Somatostatin Analogue Octreotide Inhibits Growth of Small Intestine Neuroendocrine Tumour Cells
(Public Library Of Science (PLOS), 2012)
Octreotide is a widely used synthetic somatostatin analogue that significantly improves the management of
neuroendocrine tumours (NETs). Octreotide acts through somatostatin receptors (SSTRs). However, the molecular
mechanisms ...
The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes
(SpringerLink, 2012)
Aims/hypothesis
Proinflammatory and proapoptotic cytokines such as TNF-α are upregulated in human obesity. We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and ...
The l-α-Lysophosphatidylinositol/GPR55 system and its potential role in human obesity
(American Diabetes Asociation, 2012)
GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; 2) the correlation of both GPR55 and LPI ...