Now showing items 1-15 of 15

    • Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition 

      Tapia-González, S.; García-Segura, L.M.; Tena-Sempere, Manuel; Frago, L.M.; Castellano, J.M.; Fuente-Martín, E.; García-Cáceres, C.; Argente, J.; Chowen, J.A. (Blackwell Publishing, 2011)
      Much attention has been drawn to the possible involvement of hypothalamic inflammation in the pathogenesis of metabolic disorders, especially in response to a high-fat diet. Microglia, the macrophages of the central nervous ...
    • An Approach to Early Detection of Metabolic Syndrome through Non-Invasive Methods in Obese Children 

      Molina Luque, Rafael; Ulloa, Natalia; Gleisner, Andrea; Zilic, Martin; Romero Saldaña, Manuel; Molina Recio, Guillermo (MDPI, 2020)
      Background: Metabolic Syndrome (MetS) has a high prevalence in children, and its presence increases in those with a high BMI. This fact confirms the need for early detection to avoid the development of other comorbidities. ...
    • Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation 

      Frühbeck, Gema; Balaguer, Inmaculada; Méndez-Giménez, Leire; Valentí, Víctor; Becerril, Sara; Catalán, Victoria; Gómez-Ambrosi, Javier; Silva, Camilo; Salvador, Javier; Calamita, Giuseppe; Malagón, María M.; Rodríguez, Amaia (MDPI, 2020)
      Aquaporin-11 (AQP11) is expressed in human adipocytes, but its functional role remains unknown. Since AQP11 is an endoplasmic reticulum (ER)-resident protein that transports water, glycerol, and hydrogen peroxide (H2O2), ...
    • Changes in Physical Activity Patterns from Childhood to Adolescence: Genobox Longitudinal Study 

      Llorente Cantarero, Francisco Jesús; Aguilar-Gómez, Francisco Javier; Anguita-Ruiz, Augusto; Rupérez, Azahara I.; Vázquez-Cobela, Rocío; Flores Rojas, Katherine Ubina; Aguilera, Concepción M.; González-Gil, Esther M.; Gil Campos, Mercedes; Bueno-Lozano, Gloria; Leis, Rosaura (MDPI, 2020)
      Longitudinal changes of physical activity (PA) from childhood into adolescence have not been accurately described yet for the Spanish population. The aim of this study is to evaluate the changes of PA, assessed by accelerometry ...
    • Common Variants in 22 Genes Regulate Response to Metformin Intervention in Children with Obesity: A Pharmacogenetic Study of a Randomized Controlled Trial 

      Anguita-Ruiz, Augusto; Pastor-Villaescusa, Belén; Leis, Rosaura; Bueno, Gloria; Hoyos, Raúl; Vázquez-Cobela, Rocío; Latorre Millán, Miriam; Cañete, M. Dolores; Caballero-Villarraso, Javier; Gil, Ángel; Cañete Estrada, Ramón; Aguilera, Concepción M. (MDPI, 2019)
      Metformin is a first-line oral antidiabetic agent that has shown additional effects in treating obesity and metabolic syndrome. Inter-individual variability in metformin response could be partially explained by the genetic ...
    • Epidemiologic Behavior of Obesity in the Maracaibo City Metabolic Syndrome Prevalence Study 

      Bermúdez Pirela, Valmore José; Pacheco, Maikol; Rojas, Joselyn; Córdova, Evelyn; Velázquez, Rossibel; Carrillo, Daniela; Parra, María G.; Toledo, Alexandra; Añez, Roberto; Fonseca, Eneida; París Marcano, Rafael; Cano, Clímaco; López-Miranda, José (Public Libray of Science (PLOS), 2012)
      Introduction: Obesity is a worldwide public health issue. Since the epidemiological behaviour of this disease is not well established in our country, the purpose of this study was to determinate its prevalence in the ...
    • Equation Córdoba: A Simplified Method for Estimation of Body Fat (ECORE-BF) 

      Molina Luque, Rafael; Romero Saldaña, Manuel; Álvarez-Fernández, Carlos; Bennasar-Veny, Miquel; Álvarez-López, Álvaro; Molina Recio, Guillermo (MDPI, 2019)
      Background: Many methods for measuring body fat have been developed, but applications in clinical settings are limited. For this reason, researchers have tried to identify different formulas for its estimation but most of ...
    • Genome-Wide Expression in Visceral Adipose Tissue from Obese Prepubertal Children 

      Aguilera García, Concepción; Gómez-Llorente, Carolina; Tofé, Inés; Gil Campos, Mercedes; Cañete Estrada, Ramón; Gil, Ángel (MDPI, 2015)
      Characterization of the genes expressed in adipose tissue (AT) is key to understanding the pathogenesis of obesity and to developing treatments for this condition. Our objective was to compare the gene expression in visceral ...
    • Ibero–American Consensus on Low- and No-Calorie Sweeteners: Safety, Nutritional Aspects and Benefits in Food and Beverages 

      Serra-Majem, Lluis; Raposo, Antonio; Aranceta-Bartrina, Javier; Varela-Moreiras, Gregorio; Logue, Caomhan; Laviada, Hugo; Socolovsky, Susana; Pérez-Rodrigo, Carmen; Aldrete-Velasco, Jorge Antonio; Meneses Sierra, Eduardo; López-García, Rebeca; Ortiz-Andrelluchi, Adriana; Gómez-Candela, Carmen; Abreu, Rodrigo; Alexanderson, Erick; Álvarez-Álvarez, Rolando Joel; Álvarez Falcón, Ana Luisa; Anadón, Arturo; Bellisle, France; Beristain-Navarrete, Ina Alejandra; Blasco Redondo, Raquel; Bochicchio, Tommaso; Camolas, José; Cardina, Fernando G.; Carocho, Márcio; Costa, Maria do Céu; Drewnowski, Adam; Durán, Samuel; Faundes, Víctor; Fernández-Condori, Roxana; García-Luna, Pedro P.; Garnica, Juan Carlos; González-Gross, Marcela; La Vecchia, Carlo; Leis, Rosaura; López-Sobaler, Ana María; Madero, Miguel Agustín; Marcos, Ascensión; Mariscal Ramírez, Luis Alfonso; Martyn, Danika M.; Mistura, Lorenza; Moreno Rojas, Rafael; Moreno Villares, José Manuel; Niño-Cruz, José Antonio; Oliveira, María Beatriz P.P.; Palacios Gil-Antuñano, Nieves; Pérez-Castells, Lucía; Ribas-Barba, Lourdes; Rincón Pedrero, Rodolfo; Riobó, Pilar; Rivera Medina, Juan; Tinoco de Faria, Catalina; Valdés-Ramos, Roxana; Vasco, Elsa; Wac, Sandra N.; Wakida, Guillermo; Wanden-Berghe, Carmina; Xóchihua Díaz, Luis; Zúñiga-Guajardo, Sergio; Pyrogianni, Vasiliki; Velho de Souza, Sérgio Cunha (MDPI, 2018)
      International scientific experts in food, nutrition, dietetics, endocrinology, physical activity, paediatrics, nursing, toxicology and public health met in Lisbon on 2–4 July 2017 to develop a Consensus on the use of ...
    • Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study 

      Olza, Josune; Rupérez, Azahara I.; Gil Campos, Mercedes; Leis, Rosaura; Cañete Estrada, Ramón; Tojo, Rafael; Gil, Ángel; Aguilera, Concepción M. (MDPI, 2017)
      Leptin is an endocrine hormone that has a critical role in body weight homoeostasis and mediates its effects via the leptin receptor (LEPR). Common polymorphisms in the genes coding leptin receptors have been associated ...
    • Levels of Physical Activity, Obesity and Related Factors in Young Adults Aged 18–30 During 2009–2017 

      Laredo-Aguilera, José Alberto; Cobo Cuenca, Ana Isabel; Santacruz-Salas, Esmeralda; Martins, María Manuela; Rodríguez Borrego, M.A.; López Soto, Pablo Jesús; Carmona Torres, Juan Manuel (MDPI, 2019)
      The objective of this study was to analyze the temporal trend of physical activity and body mass index in young adults aged 18–30 in Spain and to ascertain their relationship with sociodemographic and psychosocial variables ...
    • Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities 

      Opazo-Ríos, Lucas; Mas, Sebastián; Marín-Royo, Gema; Mezzano, Sergio; Gómez-Guerrero, Carmen; Moreno, Juan Antonio; Egido, J. (MDPI, 2020)
      Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose ...
    • Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users 

      Luciano-Mateo, Fedra; Hernández-Aguilera, Anna; Cabré, Noemí; Camps, Jordi; Fernández-Arroyo, Salvador; López-Miranda, José; Menéndez, Javier A.; Joven, Jorge (MDPI, 2017)
      Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive ...
    • Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue 

      Novelle, Marta G.; Vázquez, María J.; Peinado, Juan R.; Martinello, Kátia D.; López, Miguel; Luckman, Simon M.; Tena-Sempere, Manuel; Malagón, María M.; Nogueiras, Rubén; Diéguez, Carlos (Nature Research, 2017)
      During their lifetime, females are subjected to different nutritional and hormonal factors that could increase the risk of obesity and associated comorbidities. From early postnatal periods until the postmenopausal phase, ...
    • The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health 

      Clemente-Postigo, Mercedes; Tinahones, Alberto; Bekay, Rajaa El; Malagón, María M.; Tinahones, Francisco J. (MDPI, 2020)
      White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT ...