• Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma 

  López Cánovas, Juan Luis; Río Moreno, Mercedes del; García Fernández, Helena; Jiménez-Vacas, J.M.; Moreno Montilla, M. Trinidad; Sánchez-Frías, Marina; Amado-Torres, Víctor; L-López, Fernando; Fernández Fondevila, Marcos; Ciria, Rubén; Gómez-Luque, Irene; Briceño Delgado, Francisco Javier; Nogueiras, Rubén; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Elsevier, 2020)

  Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1 (SF3B1) is a crucial splicing factor that can be targeted pharmacologically (e.g. pladienolide-B). Here, we show that SF3B1 is ...

• Peptides derived from the extracellular domain of the somatostatin receptor splicing variant 1 SST5TMD4 increase malignancy in multiple cancer cell types 

  Río Moreno, Mercedes del; Alors-Pérez, Emilia; Borges de Souza, Patricia; Prados González, Mª Eugenia; Castaño, Justo P.; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Elsevier, 2019)

  Extracellular fragments derived from plasma membrane receptors can play relevant roles in the development/progression of tumor pathologies, thereby offering novel diagnostic or therapeutic opportunities. The truncated ...

• Genomic Insights into Cyanide Biodegradation in the Pseudomonas Genus 

  Sáez, Lara P.; Rodríguez Caballero, Gema; Olaya-Abril, Alfonso; Cabello, Purificación; Moreno-Vivián, Conrado; Roldán, María Dolores; Luque-Almagro, Víctor Manuel (MDPI, 2024)

  Molecular studies about cyanide biodegradation have been mainly focused on the hydrolytic pathways catalyzed by the cyanide dihydratase CynD or the nitrilase NitC. In some Pseudomonas strains, the assimilation of cyanide ...

• Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer 

  Mena-Osuna, Rafael; Mantrana, Ana; Guil-Luna, Silvia; Sánchez, María-Teresa; Navarrete, Carmen; Morales-Ruiz, T.; Rivas-Crespo, Aurora; Toledano-Fonseca, Marta; García-Ortíz, María Victoria; García Jurado, Gema; Gómez-España, M. Auxiliadora; González Fernández, Rafael A.; Villar, Carlos; Medina Fernández, Francisco Javier; Villalba, José Manuel; Aranda Aguilar, Enrique; Rodríguez-Ariza, Antonio (Wiley, 2023)

  S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible are still largely unclear. In this study, we show that GSNOR ...

• Survival analysis of productive life in Florida dairy goats using a Cox proportional hazards model 

  Ziadi, Chiraz; Sánchez, Juan Pablo; Sánchez-Rodríguez, M.; Morales Cid, Rosa; Molina Alcalá, Antonio (Wiley, 2023)

  Longevity is an economically important trait, since extending the functional life of a doe would allow us to keep the most productive females in the herd as long as possible, and this could result in the increased profitability ...

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