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Functional role and therapeutic potential of the somatostatin and ghrelin systems and their splicing variants in prostate cancer
(Universidad de Córdoba, UCOPress, 2017)
El cáncer es una de las amenazas más serias y complejas para la salud de la población mundial1. En concreto, el cáncer de próstata es el segundo tipo de tumor solido más frecuente entre los hombres, y causa 300.000 muertes ...
Identification of novel molecular markers and contribution of splicing mechanisms in endocrine-related tumoral pathologies
(Universidad de Córdoba, UCOPress, 2020)
Cancer represents one of the main challenges for the human being, in that it encompasses some of the most severe and health-threatening pathologies worldwide. Although great efforts are being implemented and significant ...
Identification of novel endocrine-metabolic and splicing machinery factors with diagnostic, prognostic and/or therapeutic potential in prostate cancer
(Universidad de Córdoba, UCOPress, 2020)
Prostate cancer (PCa) is the tumor pathology with the highest incidence among men in developed countries and represents one of the main causes of cancer-related death in this group. Despite the advances achieved during the ...
Identification of novel clinical and molecular factors for the diagnosis and aggressiveness of prostate cancer
(Universidad de Córdoba, UCOPress, 2019)
Prostate cancer (PCa) is the most common solid neoplasm in men in developed countries. Unfortunately, the extraordinary heterogeneity and complexity of PCa, together with its phenotypic/clinical variability, strongly ...
Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer
(MDPI, 2019)
Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the ...
Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer
(MDPI, 2019)
Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/agg ...
Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells
(MDPI, 2021)
A high adherence to a Mediterranean diet has been related to numerous beneficial effects in human health, including a lower incidence and mortality of prostate cancer (PCa). Olive oil is an important source of phenolic ...
Identification of novel biomarkers and therapeutic targets in the pathological interaction between the dysregulation of the endocrinemetabolic system and prostate cancer
(Universidad de Córdoba, UCOPress, 2022)
Obesity (OB) is a metabolic chronic disease with a growing incidence and elevated morbidities and mortality [1, 2]. OB is also associated with elevated economic costs for the health systems representing a worldwide public ...
Novel molecular insights on the role of splicing dysregulation in cancer
(Universidad de Córdoba, UCOPress, 2022)
Cancer and tumoral diseases represent one of most serious and complicated public health problems, being one of the leading causes of death in the world. The remarkable variety across cancer types, and the heterogeneity ...
The somatostatin/cortistatin/neuronostatin system and RNA-exosome complex as novel sources for the identification of useful diagnostic, prognostic and therapeutic tools in prostate cancer
(Universidad de Córdoba, UCOPress, 2024)
El cáncer de próstata (CaP) es una de las patologías tumorales más relevantes para el sistema sanitario, ya que cada año se registran 1.3 millones de nuevos casos y 400,000 muertes asociadas en todo el mundo. Los abordajes ...