Listar por autor "9b4585bc-2f07-420d-b0c2-b20499e420fd"

Mostrando ítems 1-20 de 25

    • A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance 

      Gahete Ortiz, Manuel D.; Córdoba-Chacón, José; Hergueta-Redondo, Marta; Martínez-Fuentes, Antonio J.; Kineman, Rhonda D.; Moreno-Bueno, Gema; Luque, Raúl M.; Castaño, Justo P. (Public Library Of Science (PLOS), 2011)
      The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a ...

    • Alternative splicing in bladder cancer: potential strategies for cancer diagnosis, prognosis, and treatment 

      Montero-Hidalgo, Antonio J.; Pérez-Gómez, Jesús M.; Martínez-Fuentes, Antonio J.; Gómez-Gómez, E.; Gahete Ortiz, Manuel D.; Jiménez-Vacas, J.M.; Luque, Raúl M. (Wiley, 2023)
      Bladder cancer is the most common malignancy of the urinary tract worldwide.The therapeutic options to tackle this disease comprise surgery, intravesical orsystemic chemotherapy, and immunotherapy. Unfortunately, a wide ...

    • Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study 

      Gahete Ortiz, Manuel D.; Río Moreno, Mercedes del; Carpio Camargo, Antonio José; Alcalá Díaz, Juan Francisco; Alors-Pérez, Emilia; Delgado-Lista, Javier; Reyes Pupo, Oscar Gabriel; Ventura, Sebastián; Pérez Martínez, Pablo; Castaño, Justo P.; López Miranda, José; Luque, Raúl M. (Elsevier, 2018)
      Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ...

    • Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer 

      Jiménez-Vacas, J.M.; Gómez Gómez, Enrique; Montero-Hidalgo, Antonio J.; Herrero-Aguayo, V.; L-López, Fernando; Sánchez-Sánchez, Rafael; Guler, Ipek; Blanca, Ana; Méndez-Vidal, María José; Carrasco, Julia; López-Miranda, José; Requena-Tapia, M.J.; Castaño, Justo P.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2019)
      Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/agg ...

    • Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells 

      León González, A.J.; Sáez Martínez, Prudencio; Jiménez-Vacas, J.M.; Herrero-Aguayo, V.; Montero-Hidalgo, Antonio J.; Gómez Gómez, Enrique; Madrona, Andrés; Castaño, Justo P.; Espartero, José L.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2021)
      A high adherence to a Mediterranean diet has been related to numerous beneficial effects in human health, including a lower incidence and mortality of prostate cancer (PCa). Olive oil is an important source of phenolic ...

    • Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study 

      Río Moreno, Mercedes del; Luque, Raúl M.; Rangel Zúñiga, Oriol Alberto; Alors-Pérez, Emilia; Alcalá Díaz, Juan Francisco; Roncero-Ramos, Irene; Camargo García, A.; Gahete Ortiz, Manuel D.; López-Miranda, José; Castaño, Justo P. (MDPI, 2020)
      Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely ...

    • Does telotristat have a role in preventing carcinoid heart disease? 

      Herrera-Martínez, Aura D.; Fuentes-Fayos, Antonio C.; Sánchez-Sánchez, Rafael; Montero-Hidalgo, Antonio J .; Sarmento-Cabral, André; Gálvez-Moreno, M. Ángeles; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2024)
      Carcinoid heart disease (CHD) is a frequent and life-threatening complication in patients with carcinoid tumors. Its clinical management is challenging is some cases since serotonin-induced valve fibrosis leads to heart ...

    • Endocrinología celular y molecular 

      García Navarro, S.; Ruiz Navarro, A.; Martínez Fuentes, A.J.; Vázquez Martínez, Rafael; Durán Prado, M.; Rodríguez Pacheco, F.; Molina Sánchez, M.; Cruz García, D.; Gutiérrez Pascual, E.; Díaz-Ruiz Ruiz, A.; Gahete Ortiz, Manuel D.; Pulido Toledano, M.; Castaño, Justo P.; Malagón, María M. (Universidad de Córdoba, 2009)
      El correcto funcionamiento y homeostasis del organismo requieren un control de la secreción hormonal, cuyos defectos producen graves desórdenes endocrinos y metabólicos. Esta regulación mediada por la interacción ...

    • Enzima GOAT como biomarcador de diagnóstico del cáncer de próstata 

      Castaño, Justo P.; Luque, Raúl M.; Gahete Ortiz, Manuel D.; Hormaechea Agulla, Daniel; Requena-Tapia, M.J.; Gómez Gómez, Enrique; Carrasco, Julia; Ibáñez, Alejandro; Moreno, María del Mar; Valero, José (Oficina de Transferencia de Resultados de la Investigación, 2020)

    • Experiencias en flipped learning 

      Burón, Isabel; Avendaño, S.; Cantarero, Irene; Gahete Ortiz, Manuel D.; Guzmán Ruiz, R.; Vázquez, M.J.; Luque, Rafael; Malagón, María M.; Villalba, José Manuel; Calzado Canale, Marco Antonio (UCOPress, 2018)
      El presente trabajo describe unas experiencias de innovación docente, de igual perfil y metodología, desarrolladas por un conjunto de profesores noveles participantes bajo la tutela experta de profesorado senior. El tipo ...

    • Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors 

      Herrera-Martínez, Aura D.; Gahete Ortiz, Manuel D.; Sánchez-Sánchez, Rafael; Alors-Pérez, Emilia; Pedraza-Arévalo, Sergio; Serrano-Blanch, Raquel; Martínez-Fuentes, Antonio J.; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2018)
      Objectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear. Methods: ...

    • In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features 

      Ibáñez-Costa, Alejandro; Gahete Ortiz, Manuel D.; Rivero-Cortés, Esther; Rincón-Fernández, David; Nelson, Richard; Beltrán, Manuel; Riva, Andrés de la; Japón, Miguel A.; Venegas-Moreno, Eva; García-Arnés, Juan A.; Soto-Moreno, Alfonso; Morgan, Jennifer; Tsomaia, Natia; Culler, Michael D.; Diéguez, Carlos; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2015)
      Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin ...

    • Journal article resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways 

      Rodríguez Pacheco, F.; Vázquez Martínez, Rafael; Martínez-Fuentes, Antonio J.; Pulido, Marina R.; Gahete Ortiz, Manuel D.; Vaudry, Hubert; Gracia-Navarro, F.; Diéguez, Carlos; Castaño, Justo P.; Malagón, María M. (Endocrine Society, 2009)
      The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also ...

    • LRP10, PGK1 and RPLP0: best reference genes in periprostatic adipose tissue under obesity and prostate cancer conditions 

      Pérez Gómez, J.M.; Porcel-Pastrana, Francisco; luz borrero, Marina De La; Montero-Hidalgo, Antonio J.; Gómez-Gómez, E.; Herrera-Martínez, Aura D.; Guzmán-Ruiz, Rocío; Malagón, María M.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2023)
      Obesity (OB) is a metabolic disorder characterized by adipose tissue dysfunction that has emerged as a health problem of epidemic proportions in recent decades. OB is associated with multiple comorbidities, including some ...

    • Molecular and Clinical Implications of Somatostatin Receptor Profile and Somatostatin Analogues Treatment in Oral Cavity Squamous Cell Carcinoma 

      Sanjuan-Sanjuan, Alba; Alors-Pérez, Emilia; Sánchez-Frías, Marina; Dean Ferrer, Alicia; Gahete Ortiz, Manuel D.; Heredero-Jung, Susana; Luque, Raúl M. (MDPI, 2021)
      Oral squamous cell carcinoma (OSCC) incidence has increased by 50% over the last decade. Unfortunately, surgery and adjuvant radiotherapy and chemotherapy are still the mainstream modality of treatment, underscoring the ...

    • Morphofunctional and Molecular Assessment of Nutritional Status in Head and Neck Cancer Patients Undergoing Systemic Treatment: Role of Inflammasome in Clinical Nutrition 

      León-Idougourram, Soraya; Pérez Gómez, J.M.; Muñoz Jiménez, Concepción; L-López, Fernando; Manzano García, Gregorio; Molina Puertas, María José; Herman-Sánchez, Natalia; Alonso-Echague, Rosario; Calañas Continente, Alfonso; Gálvez-Moreno, M. Ángeles; Luque, Raúl M.; Gahete Ortiz, Manuel D.; Herrera-Martínez, Aura D. (MDPI, 2022)
      Malnutrition in patients with head and neck cancer is frequent, multifactorial and widely associated with clinical evolution and prognosis. Accurate nutritional assessments allow for early identification of patients at ...

    • Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer 

      Gómez-Gómez, E.; Jiménez-Vacas, J.M.; Pedraza-Arévalo, Sergio; López-López, F.; Herrero-Aguayo, V.; Hormaechea Agulla, Daniel; Valero-Rosa, J.; Ibáñez-Costa, Alejandro; León González, A.J.; Sánchez-Sánchez, Rafael; Gónzalez Serrano, T.; Requena-Tapia, M.J.; Castaño, Justo P.; Carrasco-Valiente, J.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2019)
      Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the ...

    • Peptides derived from the extracellular domain of the somatostatin receptor splicing variant 1 SST5TMD4 increase malignancy in multiple cancer cell types 

      Río Moreno, Mercedes del; Alors-Pérez, Emilia; Borges de Souza, Patricia; Prados González, Mª Eugenia; Castaño, Justo P.; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Elsevier, 2019)
      Extracellular fragments derived from plasma membrane receptors can play relevant roles in the development/progression of tumor pathologies, thereby offering novel diagnostic or therapeutic opportunities. The truncated ...

    • PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing 

      López Cánovas, Juan Luis; Hermán Sánchez, Natalia; Río Moreno, Mercedes del; Fuentes-Fayos, Antonio C.; Lara López, Araceli; Sánchez-Frías, Marina; Amado-Torres, Víctor; Ciria, Rubén; Briceño Delgado, Francisco Javier; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Springer Nature, 2023)
      Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the ...

    • Role of Endogenous Cortistatin in the Regulation of Ghrelin System Expression at Pancreatic Level under Normal and Obese Conditions 

      Chanclón García, Belén; Luque, Raúl M.; Córdoba-Chacón, José; Gahete Ortiz, Manuel D.; Pozo-Salas, Ana I.; Castaño, Justo P.; Gracia-Navarro, F.; Martínez-Fuentes, Antonio J. (Public Library Of Science (PLOS), 2013)
      Ghrelin-system components [native ghrelin, In1-ghrelin, Ghrelin-O-acyltransferase enzyme (GOAT) and receptors (GHS-Rs)] are expressed in a wide variety of tissues, including the pancreas, where they exert different ...