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Humoral response (IgG) of goats experimentally infected with Fasciola hepatica against cysteine proteinases of adult fluke
(EDP sciences, 2003)
The use of cysteine proteinases from Fasciola hepatica adult flukes for the
serodiagnosis of caprine fasciolosis by means of an indirect ELISA test was studied. Two
proteolytic fractions from adult fluke homogenates, ...
A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep
(MDPI, 2021)
Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the ...
Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
(Frontiers, 2023)
Fasciola hepatica has a worldwide distribution causing important economic losses in animal production industry. Human fasciolosis is considered an emerging zoonosis in areas of Andean America, Asia, and Africa. The control ...
Fasciola hepatica primoinfections and reinfections in sheep drive distinct Th1/Th2/Treg immune responses in liver and hepatic lymph node at early and late stages
(Springer, 2023)
The expression of proinflammatory (IL-1β, IFN-γ, TNF-α) and regulatory (IL-10, TGF-β, IL-4) cytokines, as well as the
transcription factor FoxP3, was quantified in the liver and hepatic lymph node (HLN) of sheep primoinfected ...
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
(Springer, 2020)
Fasciola hepatica has been shown to have a high capacity for immunomodulation of the host response, making the development of protective vaccines extremely difficult. One of these immunomodulation mechanisms is the impairment ...
Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica
(BMC (Springer), 2024)
Gene expression for Th1/Th2 cytokines (IL-4 and IFN-ɣ), regulatory cytokines (TGF-β and IL-10) and the transcriptional factor FoxP3 was analyzed in the liver and hepatic lymph nodes (HLN) from sheep immunized with partially ...
Revealing the Prevalence of Toxoplasma in Sierra Morena’s Wild Boar: An ELISA-Based Study Using Meat Juice
(MDPI, 2024)
This research work focused on the prevalence of Toxoplasma gondii in wild boar from the Sierra Morena region. We conducted an ELISA analysis using meat juice samples. A total of 892 samples from six hunting seasons (2013–2019) ...
Advancement in Diagnosis, Treatment, and Vaccines against Fasciola hepatica: A Comprehensive Review
(MDPI, 2024)
In this review article, we aim to provide an overview of fasciolosis in ruminants. Diagnosis through new coprological methods (such as FlukefinderR, FLOTACR, and Mini-FLOTACR) remains the most suitable approach for farms. ...
Study of peritoneal macrophage immunophenotype in sheep experimentally infected with Fasciola hepatica
(Elsevier, 2018)
During Fasciola hepatica infection, the parasite has the capability to modulate the host immune response towards
a non-protector Th2 type instead of Th1. This type of immune response is closely related to the alternativ ...
Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach
(Springer, 2020)
Background: Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies
gave rise to the identification of various vaccine candidates. The recombinant form of a member ...