From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing

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Author
Catalina, Mercedes
Cot, Jaume
Borras, Miquel
Lapuente, Joaquín de
Balu, Alina M.
Luque, Rafael
Publisher
MDPIDate
2013Subject
Bio-collagenLeather waste valorisation
Wound healing
Tissue regeneration
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Show full item recordAbstract
The biomedical properties of a porous bio-collagenic polymer extracted from
leather industrial waste residues have been investigated in wound healing and tissue
regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to
induced wounds in rats dramatically improved its healing after 7 days in terms of collagen
production and wound filling as well as in the migration and differentiation of
keratinocytes. The formulation tested was found to be three times more effective than the
commercial reference product Catrix® (Heal Progress (HP): 8 ± 1.55 vs. 2.33 ± 0.52,
p < 0.001; Formation of Collagen (FC): 7.5 ± 1.05 vs. 2.17 ± 0.75, p < 0.001; Regeneration
of Epidermis (RE): 13.33 ± 5.11 vs. 5 ± 5.48, p < 0.05).