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dc.contributor.authorOlmedo, Dionisio
dc.contributor.authorSancho, Rocío
dc.contributor.authorBedoya, Luis M.
dc.contributor.authorLópez-Pérez, José L.
dc.contributor.authorOlmo, Esther del
dc.contributor.authorMuñoz, Eduardo
dc.contributor.authorGupta, Mahabir P.
dc.contributor.authorSan Feliciano, Arturo
dc.contributor.authorAlcamí, José
dc.date.accessioned2017-11-06T13:08:32Z
dc.date.available2017-11-06T13:08:32Z
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10396/15313
dc.description.abstractWe have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κB inhibition, four resulted Tat antagonists and three of them showed both activities. Three compounds inhibited HIV replication with IC50 values < 25 μM. The antiviral effect of the 4-hydroxycoumarin derivative 19 correlates with its specific inhibition of Tat functions, while compound 8, 3-(2-chlorophenyl)coumarin, seems to act through a mechanism unrelated to the molecular targets considered in this research.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceMolecules 17(8), 9245-9257 (2012)es_ES
dc.subject3-phenylcoumarinses_ES
dc.subjectAIDSes_ES
dc.subjectTat proteines_ES
dc.subjectNF-κB inhibitiones_ES
dc.subjectAnti-HIV activityes_ES
dc.title3-Phenylcoumarins as Inhibitors of HIV-1 Replicationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/molecules17089245es_ES
dc.relation.projectIDGobierno de España. RD06/0006 (RETICS)es_ES
dc.relation.projectIDGobierno de España. RD06/0021/0022 (RETICS)es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI05/1526es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI06/0782es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI08/0752es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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