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dc.contributor.authorLozano Baena, María Dolores
dc.contributor.authorTasset, Inmaculada
dc.contributor.authorObregón Cano, Sara
dc.contributor.authorHaro Bailón, Antonio de
dc.contributor.authorMuñoz Serrano, Andrés
dc.contributor.authorAlonso Moraga, Ángeles
dc.date.accessioned2017-11-06T13:58:05Z
dc.date.available2017-11-06T13:58:05Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10396/15317
dc.description.abstractCruciferous vegetables are well known and worldwide consumed due to their health benefits and cancer prevention properties. As a desirable cruciferous plant, Ethiopian mustard (Brassica carinata A. Braun) and its glucosinolate sinigrin were tested in the in vivo Drosophila melanogaster (SMART) and the in vitro HL60 (human promyelocytic leukaemia cell line) systems. High performance liquid chromatography (HPLC) analysis of plant samples confirmed the presence of sinigrin as principal B. carinata glucosinolate. SMART was performed by feeding D. melanogaster larvae either with different concentrations of plant/compound samples or combining them with hydrogen peroxide (a potent oxidative mutagen) being both antimutagenics. HL60 assays showed the tumoricidal activity of plant samples (IC50 = 0.28 mg·mL−1) and the breakdown products of sinigrin hydrolysis (IC50 = 2.71 μM). Our results enhance the potential of B. carinata as health promoter and chemopreventive in both systems and the leading role of sinigrin in these effects.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceMolecules 20, 15748-15765 (2015)es_ES
dc.subjectDrosophila melanogasteres_ES
dc.subjectHL60es_ES
dc.subjectAntigenotoxicityes_ES
dc.subjectCytotoxicityes_ES
dc.subjectBrassicaes_ES
dc.subjectSinigrines_ES
dc.subjectBioactive compoundes_ES
dc.titleAntigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/molecules200915748es_ES
dc.relation.projectIDJunta de Andalucía. AM46/04es_ES
dc.relation.projectIDJunta de Andalucía. A55/02es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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