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A PR-1-like Protein of Fusarium oxysporum Functions in Virulence on Mammalian Hosts

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Author
Prados Rosales, Rafael
Roldán-Rodríguez, Raquel
Serena, Carolina
Sánchez López-Berges, M.
Guarro, Josep
Martínez-del-Pozo, Álvaro
Di Pietro, Antonio
Publisher
The American Society for Biochemistry and Molecular Biology
Date
2012
Subject
Fungi
Infectious Diseases
Pathogen-associated Molecular Pattern (PAMP)
Pathogenesis
Signaling
Virulence Factors
Fusarium
PR-1 Protein
Plant Pathogen
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Abstract
The pathogenesis-related PR-1-like protein family comprises secreted proteins from the animal, plant, and fungal kingdoms whose biological function remains poorly understood. Here we have characterized a PR-1-like protein, Fpr1, from Fusarium oxysporum, an ubiquitous fungal pathogen that causes vascular wilt disease on a wide range of plant species and can produce life-threatening infections in immunocompromised humans. Fpr1 is secreted and proteolytically processed by the fungus. The fpr1 gene is required for virulence in a disseminated immunodepressed mouse model, and its function depends on the integrity of the proposed active site of PR-1-like proteins. Fpr1 belongs to a gene family that has expanded in plant pathogenic Sordariomycetes. These results suggest that secreted PR-1-like proteins play important roles in fungal pathogenicity
URI
http://hdl.handle.net/10396/15455
Fuente
Journal of Biological Chemistry 287 (26), 21970-21979 (2012)
Versión del Editor
http://dx.doi.org/10.1074/jbc.M112.364034
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