A PR-1-like Protein of Fusarium oxysporum Functions in Virulence on Mammalian Hosts

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Author
Prados Rosales, Rafael
Roldán-Rodríguez, Raquel
Serena, Carolina
Sánchez López-Berges, M.
Guarro, Josep
Martínez-del-Pozo, Álvaro
Di Pietro, Antonio
Publisher
The American Society for Biochemistry and Molecular BiologyDate
2012Subject
FungiInfectious Diseases
Pathogen-associated Molecular Pattern (PAMP)
Pathogenesis
Signaling
Virulence Factors
Fusarium
PR-1 Protein
Plant Pathogen
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Show full item recordAbstract
The pathogenesis-related PR-1-like protein family comprises
secreted proteins from the animal, plant, and fungal kingdoms
whose biological function remains poorly understood. Here we
have characterized a PR-1-like protein, Fpr1, from Fusarium
oxysporum, an ubiquitous fungal pathogen that causes vascular
wilt disease on a wide range of plant species and can produce
life-threatening infections in immunocompromised humans.
Fpr1 is secreted and proteolytically processed by the fungus.
The fpr1 gene is required for virulence in a disseminated immunodepressed
mouse model, and its function depends on the
integrity of the proposed active site of PR-1-like proteins. Fpr1
belongs to a gene family that has expanded in plant pathogenic
Sordariomycetes. These results suggest that secreted PR-1-like
proteins play important roles in fungal pathogenicity