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dc.contributor.authorTena-Sempere, Manuel
dc.contributor.authorFelip, Alicia
dc.contributor.authorGómez, Ana
dc.contributor.authorZanuy, Silvia
dc.contributor.authorCarrillo, Manuel
dc.date.accessioned2017-11-22T09:32:04Z
dc.date.available2017-11-22T09:32:04Z
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10396/15484
dc.description.abstractKisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as ligands of the G protein‐coupled receptor 54 (GPR54; also termed Kiss1R) with ability to suppress tumor metastasis. In late 2003, the indispensable role of kisspeptins in the control of reproductive function was disclosed by the seminal observations that humans and mice carrying inactivating mutations of GPR54 displayed hypogonadotropic hypogonadism. Since then, numerous experimental studies, conducted initially in several mammalian species, have substantiated the roles of kisspeptins as essential players in the physiologic regulation of key aspects of reproductive maturation and function, including the timing of puberty onset, the dynamic control of gonadotropin secretion via stimulation of GnRH neurons, the transmission of the negative and positive feedback effects of sex steroids, the metabolic regulation of fertility and the control of reproductive function by environmental (photoperiodic) cues. Notably, while studies about kisspeptins in non‐mammals appeared initially to lag behind, significant efforts have been devoted recently to define the genomic organization and functional characteristics of kiss/kisspeptins and gpr54 in different non‐mammalian species, including fish, reptiles and amphibians. These analyses, which will be comprehensively revised herein, have not only substantiated the conserved, essential roles of kisspeptins in the control of reproduction, but have also disclosed intriguing evolutionary aspects of kisspeptins and their receptors. Such comparative approaches will be instrumental to fuel further studies on the molecular regulation and physiological roles of kisspeptins, thus helping to unveil the complex biology of this system as indispensable regulator of the reproductive axis in a wide diversity of animal species.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceGeneral and Comparative Endocrinology 175, 234-243 (2012)es_ES
dc.subjectKisspeptinses_ES
dc.subjectKisspeptin receptorses_ES
dc.subjectVertebrate evolutiones_ES
dc.subjectExpressiones_ES
dc.subjectKisspeptin regulationes_ES
dc.subjectIntracellular signalinges_ES
dc.titleComparative insights of the kisspeptin/kisspeptin receptor system: lessons from non-mammalian vertebrateses_ES
dc.typeinfo:eu-repo/semantics/preprintes_ES
dc.relation.projectIDGobierno de España. BFU 2008‐00984es_ES
dc.relation.projectIDGobierno de España. AGL2009‐11086es_ES
dc.relation.projectIDJunta de Andalucía. P08‐CVI‐03788es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/212844 (DEER)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/222719 (LIFECYCLE)es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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