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A PR-1-like Protein of Fusarium oxysporum Functions in Virulence on Mammalian Hosts
dc.contributor.author | Prados Rosales, Rafael | |
dc.contributor.author | Roldán-Rodríguez, Raquel | |
dc.contributor.author | Serena, Carolina | |
dc.contributor.author | Sánchez López-Berges, M. | |
dc.contributor.author | Guarro, Josep | |
dc.contributor.author | Martínez-del-Pozo, Álvaro | |
dc.contributor.author | Di Pietro, Antonio | |
dc.date.accessioned | 2017-11-22T10:13:11Z | |
dc.date.available | 2017-11-22T10:13:11Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://hdl.handle.net/10396/15486 | |
dc.description.abstract | The pathogenesis-related PR-1-like protein family comprises secreted proteins from the animal, plant, and fungal kingdoms whose biological function remains poorly understood. Here we have characterized a PR-1-like protein, Fpr1, from Fusarium oxysporum, an ubiquitous fungal pathogen that causes vascular wilt disease on a wide range of plant species and can produce life-threatening infections in immunocompromised humans. Fpr1 is secreted and proteolytically processed by the fungus. The fpr1 gene is required for virulence in a disseminated immunodepressed mouse model, and its function depends on the integrity of the proposed active site of PR-1-like proteins. Fpr1 belongs to a gene family that has expanded in plant pathogenic Sordariomycetes. These results suggest that secreted PR-1-like proteins play important roles in fungal pathogenicity. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Biochemistry and Molecular Biology Online | es_ES |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.source | The journal of biological chemistry 287 (26), 21970–21979 (2012) | es_ES |
dc.subject | Fungi | es_ES |
dc.subject | Infectious Diseases | es_ES |
dc.subject | Pathogen-associated Molecular Pattern (PAMP) | es_ES |
dc.subject | Pathogenesis | es_ES |
dc.subject | Signaling | es_ES |
dc.subject | Virulence Factors | es_ES |
dc.subject | Fusarium | es_ES |
dc.subject | PR-1 Protein | es_ES |
dc.subject | Plant Pathogen | es_ES |
dc.title | A PR-1-like Protein of Fusarium oxysporum Functions in Virulence on Mammalian Hosts | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1074/jbc.M112.364034 | es_ES |
dc.relation.projectID | Gobierno de España. BIO2010-15505 | es_ES |
dc.relation.projectID | Gobierno de España. BIO2008-04479-E | es_ES |
dc.relation.projectID | Junta de Andalucía. BIO-3847 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/PEOPLE-ITN-237936 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |