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dc.contributor.authorPrados Rosales, Rafael
dc.contributor.authorRoldán-Rodríguez, Raquel
dc.contributor.authorSerena, Carolina
dc.contributor.authorSánchez López-Berges, M.
dc.contributor.authorGuarro, Josep
dc.contributor.authorMartínez-del-Pozo, Álvaro
dc.contributor.authorDi Pietro, Antonio
dc.date.accessioned2017-11-22T10:13:11Z
dc.date.available2017-11-22T10:13:11Z
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10396/15486
dc.description.abstractThe pathogenesis-related PR-1-like protein family comprises secreted proteins from the animal, plant, and fungal kingdoms whose biological function remains poorly understood. Here we have characterized a PR-1-like protein, Fpr1, from Fusarium oxysporum, an ubiquitous fungal pathogen that causes vascular wilt disease on a wide range of plant species and can produce life-threatening infections in immunocompromised humans. Fpr1 is secreted and proteolytically processed by the fungus. The fpr1 gene is required for virulence in a disseminated immunodepressed mouse model, and its function depends on the integrity of the proposed active site of PR-1-like proteins. Fpr1 belongs to a gene family that has expanded in plant pathogenic Sordariomycetes. These results suggest that secreted PR-1-like proteins play important roles in fungal pathogenicity.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Biochemistry and Molecular Biology Onlinees_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceThe journal of biological chemistry 287 (26), 21970–21979 (2012)es_ES
dc.subjectFungies_ES
dc.subjectInfectious Diseaseses_ES
dc.subjectPathogen-associated Molecular Pattern (PAMP)es_ES
dc.subjectPathogenesises_ES
dc.subjectSignalinges_ES
dc.subjectVirulence Factorses_ES
dc.subjectFusariumes_ES
dc.subjectPR-1 Proteines_ES
dc.subjectPlant Pathogenes_ES
dc.titleA PR-1-like Protein of Fusarium oxysporum Functions in Virulence on Mammalian Hostses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1074/jbc.M112.364034es_ES
dc.relation.projectIDGobierno de España. BIO2010-15505es_ES
dc.relation.projectIDGobierno de España. BIO2008-04479-Ees_ES
dc.relation.projectIDJunta de Andalucía. BIO-3847es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/PEOPLE-ITN-237936es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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