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dc.contributor.authorSchäfer, Katja
dc.contributor.authorDi Pietro, Antonio
dc.contributor.authorGow, Neil A. R.
dc.contributor.authorMacCallum, Donna
dc.date.accessioned2017-11-22T10:54:08Z
dc.date.available2017-11-22T10:54:08Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10396/15490
dc.description.abstractThe soil-borne plant pathogen Fusarium oxysporum causes life-threatening invasive fusariosis in immunocompromised individuals. The mechanism of infection in mammalian hosts is largely unknown. In the present study we show that the symptoms of disseminated fusariosis caused by F. oxysporum in immunosuppressed mice are remarkably similar to those reported in humans. Distinct fungal structures were observed inside the host, depending on the infected organ. Invasive hyphae developed in the heart and kidney, causing massive colonization of the organs. By contrast, chlamydospore-like survival structures were found in lung, spleen and liver. Systemically infected mice also developed skin and eye infections, as well as thrombosis and necrosis in the tail. We further show that F. oxysporum can disseminate and persist in the organs of immunocompetent animals, and that these latent infections can lead to lethal systemic fusariosis if the host is later subjected to immunosuppressive treatment.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherPLOSes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourcePLoS ONE9(2): e89920 (2014)es_ES
dc.subjectFungal structurees_ES
dc.subjectFusariumes_ES
dc.subjectImmunosuppressiveses_ES
dc.subjectFungal diseaseses_ES
dc.subjectKidneyses_ES
dc.subjectSpleenes_ES
dc.subjectSkin infectionses_ES
dc.subjectFusarium oxysporumes_ES
dc.titleMurine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistencees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0089920es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-PEOPLE-ITN-237936es_ES
dc.relation.projectIDGobienro de España. BIO2010-15505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/HEALTH-F2- 2010-260338es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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