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dc.contributor.authorMateo-Fernández, Marcos
dc.contributor.authorMerinas Amo, María Tania
dc.contributor.authorMoreno-Millán, M.
dc.contributor.authorAlonso Moraga, Ángeles
dc.contributor.authorDemyda-Peyrás, S.
dc.date.accessioned2017-12-05T13:26:52Z
dc.date.available2017-12-05T13:26:52Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10396/15662
dc.description.abstractThe aim of this work was to assess the biological and food safety of two different beverages: Classic Coca Cola™ (CCC) and Caffeine-Free Coca Cola (CFCC). To this end, we determined the genotoxicological and biological effects of different doses of lyophilised CCC and CFCC and Caffeine (CAF), the main distinctive constituent. Their toxic/antitoxic, genotoxic/antigenotoxic, and chronic toxicity (lifespan assay) effects were determined in vivo using the Drosophila model. Their cytotoxic activities were determined using the HL-60 in vitro cancer model. In addition, clastogenic DNA toxicity was measured using internucleosomal fragmentation and SCGE assays. Their epigenetic effects were assessed on the HL-60 methylation status using some repetitive elements. The experimental results showed a slight chemopreventive effect of the two cola beverages against HL-60 leukaemia cells, probably mediated by nonapoptotic mechanisms. Finally, CCC and CAF induced a global genome hypomethylation evaluated in LINE-1 and Alu M1 repetitive elements. Overall, we demonstrated for the first time the safety of this famous beverage in in vivo and in vitro models.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherHindawies_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceBioMed Research International 2016, 1-15 (2016)es_ES
dc.subjectBeverageses_ES
dc.subjectCola beverageses_ES
dc.subjectCaffeinees_ES
dc.subjectGenotoxicological effectses_ES
dc.subjectBiological effectses_ES
dc.titleIn Vivo and In Vitro Genotoxic and Epigenetic Effects of Two Types of Cola Beverages and Caffeine: A Multiassay Approaches_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1155/2016/7574843es_ES
dc.relation.projectIDJunta de Andalucía. PAIDI-AGR-158es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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