Hepatopancreatic ganglioneuroma in a young dog: a case report
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Autor
Zafra Leva, Rafael
Bautista Pérez, María José
Pérez, José
Ginel Pérez, Pedro J.
Lucena Solís, Rosario
Editor
Czech Academy of Agricultural Sciences.Fecha
2011Materia
GanglioneuromaDog
Immunohistochemistry
Liver
Pancreas
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The clinical, pathological and immunohistochemical features of a hepatobiliary and pancreatic ganglioneuroma
in a seven-month-old dog are described. The dog presented progressive weight loss, anorexia and abdominal
pain. At laparoscopic examination numerous whitish nodules ranging from 0.5 to 1 cm in diameter were found in the
peripancreatic tissues, the bile duct system and perihepatic tissues. Due to poor prognosis the dog was euthanized and
necropsy was conducted. Tumour nodules were not noted in the other examined abdominal organs. Microscopically,
the nodules were composed of large, well differentiated neurons embedded in an abundant stroma of nerve fibres and
connective fibrous tissue. Through immunohistochemistry analysis, neurons were found to express neurofilaments
and did not express S-100 protein. The histopathological and immunohistochemical features were consistent with a
diagnosis of ganglioneuroma. This case is atypical as the majority of reported canine ganglioneuromas involve the
gastrointestinal tract. The early age of the dog is also considered to be atypical for this tumour