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Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa

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Author
Ferreira Garcia, Luane
Peixoto da Cunha, Carlos Eduardo
Kussmaul Gonçalves Moreno, Emily
Vieira Thomaz, Douglas
Sanz Lobón, Germán
Luque, Rafael
Somerset, Vernon
Souza Gil, Eric de
Publisher
MDPI
Date
2018
Subject
Pencil graphite
Metal oxide nanostructures
Low cost
Phenolic drug
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Abstract
Methyldopa is a catecholamine widely used in the treatment of mild to moderate hypertension whose determination in pharmaceutical formulae is of upmost importance for dose precision. Henceforth, a low-cost carbon paste electrode (CPE) consisting of graphite powder obtained from a crushed pencil stick was herein modified with nanostructured TiO2 (TiO2@CPE) aiming for the detection of methyldopa in pharmaceutical samples. The TiO2-modified graphite powder was characterized by scanning electron microscopy and X-ray diffraction, which demonstrated the oxide nanostructured morphology. Results evidenced that sensitivity was nonetheless increased due to electro-catalytic effects promoted by metal modification, and linear response obtained by differential pulse voltammetry for the determination of methyldopa (pH = 5.0) was between 10–180 mol/L (Limit of Detection = 1 mol/L) with the TiO2@CPE sensor. Furthermore, the constructed sensor was successfully applied in the detection of methyldopa in pharmaceutical formulations and excipients promoted no interference, that indicates that the sensor herein developed is a cheap, reliable, and useful strategy to detect methyldopa in pharmaceutical samples, and may also be applicable in determinations of similar compounds.
URI
http://hdl.handle.net/10396/17372
Fuente
Pharmaceuticals 11, 99 (2018)
Versión del Editor
http://dx.doi.org/10.3390/ph11040099
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