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dc.contributor.authorFerreira Garcia, Luane
dc.contributor.authorPeixoto da Cunha, Carlos Eduardo
dc.contributor.authorKussmaul Gonçalves Moreno, Emily
dc.contributor.authorVieira Thomaz, Douglas
dc.contributor.authorSanz Lobón, Germán
dc.contributor.authorLuque, Rafael
dc.contributor.authorSomerset, Vernon
dc.contributor.authorSouza Gil, Eric de
dc.date.accessioned2018-10-31T12:14:27Z
dc.date.available2018-10-31T12:14:27Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10396/17372
dc.description.abstractMethyldopa is a catecholamine widely used in the treatment of mild to moderate hypertension whose determination in pharmaceutical formulae is of upmost importance for dose precision. Henceforth, a low-cost carbon paste electrode (CPE) consisting of graphite powder obtained from a crushed pencil stick was herein modified with nanostructured TiO2 (TiO2@CPE) aiming for the detection of methyldopa in pharmaceutical samples. The TiO2-modified graphite powder was characterized by scanning electron microscopy and X-ray diffraction, which demonstrated the oxide nanostructured morphology. Results evidenced that sensitivity was nonetheless increased due to electro-catalytic effects promoted by metal modification, and linear response obtained by differential pulse voltammetry for the determination of methyldopa (pH = 5.0) was between 10–180 mol/L (Limit of Detection = 1 mol/L) with the TiO2@CPE sensor. Furthermore, the constructed sensor was successfully applied in the detection of methyldopa in pharmaceutical formulations and excipients promoted no interference, that indicates that the sensor herein developed is a cheap, reliable, and useful strategy to detect methyldopa in pharmaceutical samples, and may also be applicable in determinations of similar compounds.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourcePharmaceuticals 11, 99 (2018)es_ES
dc.subjectPencil graphitees_ES
dc.subjectMetal oxide nanostructureses_ES
dc.subjectLow costes_ES
dc.subjectPhenolic druges_ES
dc.titleNanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/ph11040099es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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