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dc.contributor.authorMartín, Juan Francisco
dc.contributor.authorMuñoz-Bravo, José L.
dc.contributor.authorIbáñez-Costa, Alejandro
dc.contributor.authorFernández-Maza, Laura
dc.contributor.authorBalcerzyk, Marcin
dc.contributor.authorLeal Campanario, Rocío
dc.contributor.authorLuque, Raúl M.
dc.contributor.authorCastaño, Justo P.
dc.contributor.authorVenegas-Moreno, Eva
dc.contributor.authorSoto-Moreno, Alfonso
dc.contributor.authorLeal-Cerro, Alfonso
dc.contributor.authorCano, David A.
dc.date.accessioned2020-04-01T09:59:33Z
dc.date.available2020-04-01T09:59:33Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10396/19857
dc.description.abstractAcromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by pituitary adenomas. Elevated GH and IGF-I levels results in wide range of somatic, cardiovascular, endocrine, metabolic and gastrointestinal morbidities. Subcutaneous implantation of the GH-secreting GC cell line in rats leads to the formation of tumors. GC tumor-bearing rats develop characteristics that resemble human acromegaly including gigantism and visceromegaly. However, GC tumors remain poorly characterized at a molecular level. In the present work, we report a detailed histological and molecular characterization of GC tumors using immunohistochemistry, molecular biology and imaging techniques. GC tumors display histopathological and molecular features of human GH-producing tumors, including hormone production, cell architecture, senescence activation and alterations in cell cycle gene expression. Furthermore, GC tumors cells displayed sensitivity to somatostatin analogues, drugs that are currently used in the treatment of human GH-producing adenomas, thus supporting the GC tumor model as a translational tool to evaluate therapeutic agents. The information obtained would help to maximize the usefulness of the GC rat model for research and preclinical studies in GH-secreting tumors.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherNature Researches_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceScientific Reports 5, 16298 (2015)es_ES
dc.subjectCanceres_ES
dc.subjectPituitary tumourses_ES
dc.subjectGC tumorses_ES
dc.subjectAcromegalyes_ES
dc.subjectGrowth hormonees_ES
dc.subjectInsulin-like growth factor 1es_ES
dc.titleMolecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegalyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1038/srep16298es_ES
dc.relation.projectIDJunta de Andalucía. CTS-7478es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI12/0143es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI13/02043es_ES
dc.relation.projectIDJunta de Andalucía. CTS-444es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI1300651es_ES
dc.relation.projectIDJunta de Andalucía. C-0015-2014es_ES
dc.relation.projectIDJunta de Andalucía. PI0302-2012es_ES
dc.relation.projectIDJunta de Andalucía. CTS-1406es_ES
dc.relation.projectIDJunta de Andalucía. PI-0639-2012es_ES
dc.relation.projectIDJunta de Andalucía. BIO-0139es_ES
dc.relation.projectIDGobierno de España. BFU2013-43282-Res_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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