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dc.contributor.authorMateo-Fernández, Marcos
dc.contributor.authorValenzuela-Gómez, Fernando
dc.contributor.authorFont, Rafael
dc.contributor.authorRío-Celestino, Mercedes del
dc.contributor.authorMerinas Amo, María Tania
dc.contributor.authorAlonso Moraga, Ángeles
dc.date.accessioned2021-04-12T10:54:13Z
dc.date.available2021-04-12T10:54:13Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10396/21249
dc.description.abstractTaurine is one of the main ingredients used in energy drinks which are highly consumed in adolescents for their sugary taste and stimulating effect. With energy drinks becoming a worldwide phenomenon, the biological effects of these beverages must be evaluated in order to fully comprehend the potential impact of these products on the health due to the fact nutrition is closely related to science since the population consumes food to prevent certain diseases. Therefore, the aim of this study was to evaluate the biological effects of taurine, glucose, classic Red Bull® and sugar-free Red Bull® in order to check the food safety and the nutraceutical potential of these compounds, characterising different endpoints: (i) Toxicology, antitoxicology, genotoxicology and life expectancy assays were performed in the Drosophila melanogaster model organism; (ii) The in vitro chemopreventive activity of testing compounds was determined by assessing their cytotoxicity, the proapoptotic DNA-damage capability to induce internucleosomal fragmentation, the strand breaks activity and the modulator role on the methylation status of genomic repetitive sequences of HL-60 promyelocytic cells. Whereas none tested compounds showed toxic or genotoxic effect, all tested compounds exerted antitoxic and antigenotoxic activity in Drosophila. Glucose, classic Red Bull® and sugar-free Red Bull® were cytotoxic in HL-60 cell line. Classic Red Bull® induced DNA internucleosomal fragmentation although none of them exhibited DNA damage on human leukaemia cells. In conclusion, the tested compounds are safe on Drosophila melanogaster and classic Red Bull® could overall possess nutraceutical potential in the in vivo and in vitro model used in this study. Besides, taurine could holistically be one of the bioactive compounds responsible for the biological activity of classic Red Bull®.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceMolecules 26(8), 2198 (2021)es_ES
dc.subjectClassic Red Bull®es_ES
dc.subjectTaurinees_ES
dc.subjectGlucosees_ES
dc.subjectDrosophila melanogasteres_ES
dc.subjectHL-60 cell linees_ES
dc.titleIn Vivo and In Vitro Assays Evaluating the Biological Activity of Taurine, Glucose and Energetic Beverageses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/molecules26082198es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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