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dc.contributor.authorCimadamore, Alessia
dc.contributor.authorMazzucchelli, Roberta
dc.contributor.authorLópez-Beltrán, Antonio
dc.contributor.authorMassari, Francesco
dc.contributor.authorSantoni, Matteo
dc.contributor.authorScarpelli, Marina
dc.contributor.authorCheng, Liang
dc.contributor.authorMontironi, Rodolfo
dc.date.accessioned2021-07-12T09:03:47Z
dc.date.available2021-07-12T09:03:47Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10396/21466
dc.description.abstractThe 2021 novelties in prognostic and therapeutic tissue markers in patients with prostate cancer (PCa) can be subdivided into two major groups. The first group is related to prognostic markers based on morphological and immunohistochemical evaluations. The novelties in this group can then be subdivided into two subgroups, one involving morphologic evaluation only, i.e., PCa grading, and the other involving both morphologic and immunohistochemical evaluations, i.e., aggressive variant PCa (AVPCa). Grading concerns androgen-dependent PCa, while AVPCa represents a late phase in its natural history, when it becomes androgen-independent. The novelties of the other major group are related to molecular markers predicting significant disease or response to therapy. This group mainly includes novelties in the molecular evaluation of PCa in tissue material and liquid biopsies.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceCancers 13(14), 3471 (2021)es_ES
dc.subjectProstate canceres_ES
dc.subjectGleason grading systemes_ES
dc.subjectGrade groupses_ES
dc.subjectAggressive variant prostate canceres_ES
dc.subjectDNA damage repair pathwayes_ES
dc.subjectDNA mismatch repaires_ES
dc.subjectPARPies_ES
dc.subjectImmunotherapyes_ES
dc.titleProstate Cancer in 2021: Novelties in Prognostic and Therapeutic Biomarker Evaluationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/cancers13143471es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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