Browsing DBCFI-Artículos, capítulos, libros... by Title
Now showing items 1-20 of 257
-
3-Phenylcoumarins as Inhibitors of HIV-1 Replication
(MDPI, 2012)We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition ... -
5—hidroxitriptamina en encéfalo total y en diversas regiones del sistema nervioso central de ratas intoxicadas con el extracto acuoso de Astragalus lusitanicus Lam
(Universidad de Córdoba, Servicio de Publicaciones, 1986)The administration of the aqueous extract of Astragalus lusitanicus to rats, in a dose" corresponding to 45 g wet plant/kg body weight, brougW about the sintomatology of a central nervous system depression that persisted ... -
A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing disease patients: key role of AVPR1b receptor and potential therapeutic implications
(Oxford, 2013)Context: Desmopressin is a synthetic agonist of vasopressin receptors (AVPRs). The desmopressin stimulation test is used in the diagnosis and postsurgery prognosis of Cushing disease (CD). However, the cellular and molecular ... -
A genome-wide association study of mare fertility in the Pura Raza Español horse
(Elsevier, 2022)Despite the economic importance of fertility for the horse industry, few efforts have been made to achieve a better understanding of the genetic mechanisms underlying its control. This is probably due to the difficulty of ... -
A Meta-Analytic Approach to Predict Methane Emissions from Dairy Goats Using Milk Fatty Acid Profile
(MDPI, 2020)The aim of this work was to develop an equation to predict methane yield (CH4, g/kg dry matter intake) from dairy goats using milk fatty acid (FA) profile. Data from 12 research papers (30 treatments and 223 individual ... -
A monounsaturated fatty acid rich diet reduces macrophage uptake of plasma oxidized LDL in healthy young men
(Cambridge University Press, 2008)During atherogenesis, a pathological accumulation of lipids occurs within aortic intimal macrophages through uptake of plasma oxidised LDL (oxLDL). The aim of the present study was to determine whether macrophage uptake ... -
A Novel Cell Fixation Method that Greatly Enhances Protein Identification in Microproteomic Studies Using Laser Capture Microdissection and Mass Spectrometry
(Wiley, 2018)Microproteomic studies have improved our knowledge of cell biology. Yet, with mass spectrometry (MS) analysis, accuracy can be lost for protein identification and quantification when using heterogeneous samples. Laser ... -
A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance
(Public Library Of Science (PLOS), 2011)The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a ... -
A novel Microproteomic Approach Using Laser Capture Microdissection to Study Cellular Protrusions
(MDPI, 2019)Cell–cell communication is vital to multicellular organisms, and distinct types of cellular protrusions play critical roles during development, cell signaling, and the spreading of pathogens and cancer. The differences in ... -
A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study
(Springer, 2021)Purpose: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We ... -
A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors
(AACR, 2020)Purpose: Somatostatin analogues (SSA) are efficacious and safe treatments for a variety of neuroendocrine tumors, especially pituitary neuroendocrine tumors (PitNET). Their therapeutic effects are mainly mediated by ... -
A Straightforward Cytometry-Based Protocol for the Comprehensive Analysis of the Inflammatory Valve Infiltrate in Aortic Stenosis
(MDPI, 2023)Aortic stenosis (AS) is a frequent cardiac disease in old individuals, characterized by valvular calcification, fibrosis, and inflammation. Recent studies suggest that AS is an active inflammatory atherosclerotic-like ... -
Acciones tuteladas para la formación de profesorado novel: diseño e implementación de actividades y recursos de aprendizaje en soporte LMS
(UCOPress, 2018)El presente artículo describe el desarrollo de un Proyecto formativo para la implementación de actividades y recursos de aprendizaje en la plataforma UCO-Moodle por parte de profesorado novel, bajo tutela y coordinación ... -
Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition
(Blackwell Publishing, 2011)Much attention has been drawn to the possible involvement of hypothalamic inflammation in the pathogenesis of metabolic disorders, especially in response to a high-fat diet. Microglia, the macrophages of the central nervous ... -
Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension
(Wiley, 2012)Background and purpose: Regular physical activity is an effective non-pharmacological therapy for prevention and control of hypertension. We investigated the effects of aerobic exercise training in vascular remodelling and ... -
Aerobic exercise training increases neuronal nitric oxide release and bioavailability and decreases noradrenaline release in mesenteric artery from spontaneously hypertensive rats
(Wolters Kluwer, 2013)Objective: To study the effect of aerobic exercise training on sympathetic, nitrergic and sensory innervation function in superior mesenteric artery from spontaneously hypertensive rats (SHRs). Methods: De-endothelized ... -
Aislamiento in situ de núcleos de células HeLa
(Universidad de Córdoba, Servicio de Publicaciones, 1978)By optical microscope with phase contrast we have studied the modifications of nuclei from HeLa cells isolated in situ by means of Triton X-100. We remark the structure continuance until 60 days after isolation: The method ... -
Aldosterone alters the participation of endothelial factors in noradrenaline vasoconstriction differently in resistance arteries from normotensive and hypertensive rats
(Elsevier, 2011)This study analyzed the effect of aldosterone (0.05mg/kg per day, 3 weeks) on vasoconstriction induced by noradrenaline in mesenteric resistance arteries from WKY rats and SHR. Contraction to noradrenaline was measured in ... -
Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response
(Elsevier, 2023)Pancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of tumors with growing incidence. Recent molecular analyses provided a precise picture of their genomic and epigenomic landscape. Splicing dysregulation ...